Sphingomyelin phosphodiesterase 1

SMPD1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5JG8
Identifiers
Aliases	SMPD1, ASM, ASMASE, NPD, Sphingomyelin phosphodiesterase 1
External IDs	OMIM: 607608; MGI: 98325; HomoloGene: 457; GeneCards: SMPD1; OMA:SMPD1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	6,394,998 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	105,207,596 bp
RNA expression pattern
	Top expressed in
	beta cell; ; stromal cell of endometrium; ; apex of heart; ; right lobe of liver; ; anterior pituitary; ; tendon of biceps brachii; ; right hemisphere of cerebellum; ; right auricle; ; mucosa of transverse colon; ; left ventricle;
	Top expressed in
	choroid plexus of fourth ventricle; ; gastrula; ; interventricular septum; ; CA3 field; ; entorhinal cortex; ; perirhinal cortex; ; myocardium of ventricle; ; cardiac muscle tissue of left ventricle; ; Epithelium of choroid plexus; ; decidua;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	sphingomyelin phosphodiesterase activity; hydrolase activity, acting on glycosyl bonds; protein binding; hydrolase activity; metal ion binding; zinc ion binding; acid sphingomyelin phosphodiesterase activity; phosphoric diester hydrolase activity;
Cellular component	endosome; plasma membrane; lamellar granule; lysosomal lumen; lysosome; extracellular exosome; extracellular region; extracellular space;
Biological process	termination of signal transduction; glycosphingolipid metabolic process; positive regulation of protein dephosphorylation; ceramide biosynthetic process; nervous system development; sphingomyelin catabolic process; negative regulation of MAP kinase activity; positive regulation of apoptotic process; metabolism; signal transduction; sphingomyelin metabolic process; response to cocaine; ceramide metabolic process; cholesterol metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	6609
	20597
	ENSG00000166311
	ENSMUSG00000037049
	P17405
	Q04519
	NM_000543; NM_001007593; NM_001318087; NM_001318088; NM_001365135
	NM_011421
	NP_000534; NP_001007594; NP_001305016; NP_001305017; NP_001352064
	NP_035551
	Wikidata
View/Edit Human	View/Edit Mouse

Sphingomyelin phosphodiesterase 1 (SMPD1), also known as acid sphingomyelinase (ASM), is an enzyme that in humans is encoded by the SMPD1 gene.

Sphingomyelin phosphodiesterase 1 belongs to the sphingomyelin phosphodiesterase family.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166311 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037049 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166311 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037049 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase)".

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