Spirapril

Spirapril
Clinical data
Trade names	Renormax
AHFS/Drugs.com	International Drug Names
Pregnancy; category	D;
Routes of; administration	Oral
ATC code	C09AA11 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	50%
Metabolism	converted to spiraprilat
Elimination half-life	30 to 35 hours
Excretion	Hepatic and renal
Identifiers
	IUPAC name (8S)-7-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid;
CAS Number	83647-97-6 ;
PubChem CID	5311447;
IUPHAR/BPS	6575;
DrugBank	DB01348 ;
ChemSpider	4470933 ;
UNII	96U2K78I3V;
KEGG	D08529 ;
ChEBI	CHEBI:135756;
ChEMBL	ChEMBL431 ;
CompTox Dashboard (EPA)	DTXSID1044300 ;
Chemical and physical data
Formula	C22H30N2O5S2
Molar mass	466.61 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCC)[C@@H](N[C@H](C(=O)N2[C@H](C(=O)O)CC1(SCCS1)C2)C)CCc3ccccc3;
	InChI InChI=1S/C22H30N2O5S2/c1-3-29-21(28)17(10-9-16-7-5-4-6-8-16)23-15(2)19(25)24-14-22(30-11-12-31-22)13-18(24)20(26)27/h4-8,15,17-18,23H,3,9-14H2,1-2H3,(H,26,27)/t15-,17-,18-/m0/s1 ; Key:HRWCVUIFMSZDJS-SZMVWBNQSA-N ;
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Spirapril, sold under the brand name Renormax among others, is an ACE inhibitor antihypertensive drug used to treat hypertension. It belongs to dicarboxy group of ACE inhibitors.^{[citation needed]}

It was patented in 1980 and approved for medical use in 1995.^[1]

^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 468. ISBN 978-3-527-60749-5.