The single was released on 24 April in the UK and reached No. 64 on the UK charts.
It is a modern rendition of Notorious B.I.G.'s and Bone Thugs-n-Harmony's acclaimed collaboration on the song "Notorious Thugs". In "Notorious Thugs", Biggie changed his normally smooth flow to a faster melodic pace to emulate Bone's trademark flow and "Spit Your Game" references this by including two fast verses by Twista and Krayzie Bone.