Stargardt disease

Stargardt disease
Other names	Stargardt macular dystrophy & degeneration, juvenile macular degeneration, fundus flavimaculatus
Optical coherence tomography is used for diagnosis of Stargardt's disease.
Specialty	Ophthalmology
Symptoms	Loss of central vision, low visual acuity
Usual onset	Childhood
Duration	Lifelong
Causes	Genetic
Diagnostic method	Slit lamp
Treatment	None

Stargardt disease is the most common inherited single-gene retinal disease.^[1] In terms of the first description of the disease,^[2] it follows an autosomal recessive inheritance pattern, which has been later linked to bi-allelic ABCA4 gene variants (STGD1). However, there are Stargardt-like diseases with mimicking phenotypes that are referred to as STGD3 and STGD4, and have a autosomal dominant inheritance due to defects with ELOVL4 or PROM1 genes, respectively. It is characterized by macular degeneration that begins in childhood, adolescence or adulthood, resulting in progressive loss of vision.^[3]