Stephen Hughes may refer to:
- Stephen Hughes (footballer, born 1919) (1919–1981), English football defender, played for clubs including Liverpool, Oldham Athletic and New Brighton
- Stephen Hughes (footballer, born 1976), English football midfielder, played for clubs including Arsenal, Coventry City and Walsall
- Stephen Hughes (footballer, born 1982), Scotland international footballer, played for Rangers, Leicester City, Motherwell, Norwich City
- Stephen Hughes (footballer, born 1984), English football midfielder, played for Brentford and several non-League clubs
- Stephen Hughes (politician) (born 1952), British MEP for North East England
- Steve Hughes, Australian musician and comedian
- Steven Hughes (1954–2000), American artist