Steroidogenic factor 1

NR5A1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1YOW, 1ZDT, 4QJR, 4QK4
Identifiers
Aliases	NR5A1, AD4BP, ELP, FTZ1, FTZF1, POF7, SF-1, SF1, SPGF8, SRXY3, hSF-1, nuclear receptor subfamily 5 group A member 1, SRXX4
External IDs	OMIM: 184757; MGI: 1346833; HomoloGene: 3638; GeneCards: NR5A1; OMA:NR5A1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q33.3 Start 124,481,236 bp[1] End 124,507,420 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 B|2 24.42 cM Start 38,582,668 bp[2] End 38,604,554 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex left adrenal gland left adrenal cortex spleen left ovary right ovary anterior pituitary right testis left testis gonad Top expressed in adrenal gland perirhinal cortex Leydig cell theca folliculi entorhinal cortex Ileal epithelium choroid plexus of fourth ventricle CA3 field Gonadal ridge lactiferous gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding zinc ion binding lipid binding double-stranded DNA binding enzyme binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding steroid hormone receptor activity transcription coactivator activity phospholipid binding metal ion binding DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding chromatin binding RNA polymerase II transcription regulatory region sequence-specific DNA binding nuclear receptor activity sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription cis-regulatory region binding Cellular component nucleoplasm RNA polymerase II transcription regulator complex nucleus Biological process regulation of transcription by RNA polymerase II positive regulation of transcription, DNA-templated regulation of steroid biosynthetic process hormone metabolic process luteinization reproductive process primary sex determination tissue development multicellular organism aging cell differentiation maintenance of protein location in nucleus regulation of transcription, DNA-templated adrenal gland development transcription, DNA-templated steroid hormone mediated signaling pathway cell-cell signaling transcription by RNA polymerase II negative regulation of female gonad development transcription initiation from RNA polymerase II promoter positive regulation of male gonad development intracellular receptor signaling pathway positive regulation of transcription by RNA polymerase II sex-determination system male gonad development female gonad development positive regulation of gene expression hormone-mediated signaling pathway calcineurin-mediated signaling response to gonadotropin-releasing hormone male sex determination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2516 26423 Ensembl ENSG00000136931 ENSMUSG00000026751 UniProt Q13285 P33242 RefSeq (mRNA) NM_004959 NM_139051 NM_001316687 RefSeq (protein) NP_004950 NP_004950.2 NP_001303616 NP_620639 Location (UCSC) Chr 9: 124.48 – 124.51 Mb Chr 2: 38.58 – 38.6 Mb PubMed search [3] [4]
Wikidata
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The steroidogenic factor 1 (SF-1) protein is a transcription factor involved in sex determination by controlling the activity of genes related to the reproductive glands or gonads and adrenal glands.^[5] This protein is encoded by the NR5A1 gene, a member of the nuclear receptor subfamily, located on the long arm of chromosome 9 at position 33.3. It was originally identified as a regulator of genes encoding cytochrome P450 steroid hydroxylases, however, further roles in endocrine function have since been discovered.^[6]