Class of chemical compounds
Resveratrol is a biologically important stilbenoid.
Stilbenoids are hydroxylated derivatives of stilbene . They have a C6 –C2 –C6 structure. In biochemical terms, they belong to the family of phenylpropanoids and share most of their biosynthesis pathway with chalcones .[ 1] [ 2] Most stilbenoids are produced by plants,[ 2] [ 3] and the only known exception is the antimicrobial stilbenoid drug tapinarof which is biosynthesized by the Gram-negative bacterium Photorhabdus luminescens .[ 4] [ 5] [ 6]
^ V. S. Sobolev; B. W. Horn; T. L. Potter; S. T. Deyrup; J. B. Gloer (2006). "Production of Stilbenoids and Phenolic Acids by the Peanut Plant at Early Stages of Growth". J. Agric. Food Chem. 54 (10): 3505–3511. doi :10.1021/jf0602673 . PMID 19127717 .
^ a b Valletta, Alessio; Iozia, Lorenzo Maria; Leonelli, Francesca (January 2021). "Impact of Environmental Factors on Stilbene Biosynthesis" . Plants . 10 (1): 90. doi :10.3390/plants10010090 . PMC 7823792 . PMID 33406721 .
^ Dubrovina, A. S.; Kiselev, K. V. (October 2017). "Regulation of stilbene biosynthesis in plants" . Planta . 246 (4): 597–623. doi :10.1007/s00425-017-2730-8 . ISSN 0032-0935 . PMID 28685295 . S2CID 4015467 .
^ RICHARDSON, WILLIAM H. (1988). "Identification of an anthraquinone pigment and a hydroxystilbene antibiotic from Xenorhabdus luminescens" . Applied and Environmental Microbiology . 54 (6): 1602–1605. Bibcode :1988ApEnM..54.1602R . doi :10.1128/AEM.54.6.1602-1605.1988 . PMC 202703 . PMID 3415225 – via 0099-2240/88/061602-04$02.00/0.
^ Eleftherianos, Ioannis; Boundy, Sam; Joyce, Susan A.; Aslam, Shazia; Marshall, James W.; Cox, Russell J.; Simpson, Thomas J.; Clarke, David J.; ffrench-Constant, Richard H.; Reynolds, Stuart E. (2007-02-13). "An antibiotic produced by an insect-pathogenic bacterium suppresses host defenses through phenoloxidase inhibition" . Proceedings of the National Academy of Sciences . 104 (7): 2419–2424. Bibcode :2007PNAS..104.2419E . doi :10.1073/pnas.0610525104 . ISSN 0027-8424 . PMC 1892976 . PMID 17284598 .
^ Mori, Takahiro; Awakawa, Takayoshi; Shimomura, Koichiro; Saito, Yuri; Yang, Dengfeng; Morita, Hiroyuki; Abe, Ikuro (2016-12-22). "Structural Insight into the Enzymatic Formation of Bacterial Stilbene" . Cell Chemical Biology . 23 (12): 1468–1479. doi :10.1016/j.chembiol.2016.10.010 . ISSN 2451-9456 . PMID 27866911 .