Group of proteins
Streptolysins are two homogenous exotoxins from Streptococcus pyogenes [ 1] [ 2] slo ), which is oxygen-labile, and streptolysin S (SLS; sagA ), which is oxygen-stable.[ 3]
SLO is part of the thiol-activated cytolysin family.[ 4] antistreptolysin O can be detected in an antistreptolysin O titre .
SLS is stable in the presence of oxygen. It is not antigenic due to its small size. It is sometimes considered a bacteriocin due to similarities in the synthesis pathway.[ 5]
^ "streptolysin" at Dorland's Medical Dictionary ^ Streptolysin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)^ Sierig G, Cywes C, Wessels MR, Ashbaugh CD (January 2003). "Cytotoxic effects of streptolysin o and streptolysin s enhance the virulence of poorly encapsulated group a streptococci" . Infection and Immunity . 71 (1): 446–55. doi :10.1128/IAI.71.1.446-455.2003 . PMC 143243 PMID 12496195 . ^ Billington SJ, Jost BH, Songer JG (January 2000). "Thiol-activated cytolysins: structure, function and role in pathogenesis" . FEMS Microbiology Letters . 182 (2): 197–205. doi :10.1111/j.1574-6968.2000.tb08895.x PMID 10620666 . ^ Lee SW, Mitchell DA, Markley AL, Hensler ME, Gonzalez D, Wohlrab A, et al. (April 2008). "Discovery of a widely distributed toxin biosynthetic gene cluster" . Proceedings of the National Academy of Sciences of the United States of America . 105 (15): 5879–84. doi :10.1073/pnas.0801338105 PMC 2311365 PMID 18375757 .