Succinate dehydrogenase complex subunit C

SDHC
Identifiers
Aliases	SDHC, CYB560, CYBL, PGL3, QPS1, SDH3, succinate dehydrogenase complex subunit C
External IDs	OMIM: 602413; MGI: 1913302; HomoloGene: 2256; GeneCards: SDHC; OMA:SDHC - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 161,314,381 bp[1] End 161,363,206 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H3 Start 170,954,734 bp[2] End 170,978,172 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans right adrenal cortex human kidney left adrenal gland left adrenal cortex rectum smooth muscle tissue duodenum left ventricle right lobe of liver Top expressed in soleus muscle interventricular septum plantaris muscle atrium muscle of thigh myocardium of ventricle digastric muscle sternocleidomastoid muscle extensor digitorum longus muscle temporal muscle More reference expression data BioGPS n/a
Gene ontology Molecular function electron transfer activity oxidoreductase activity, acting on the CH-CH group of donors succinate dehydrogenase activity heme binding metal ion binding succinate dehydrogenase (ubiquinone) activity ubiquinone binding Cellular component integral component of membrane mitochondrial inner membrane respiratory chain complex II succinate dehydrogenase complex mitochondrion membrane mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) Biological process aerobic respiration tricarboxylic acid cycle mitochondrial electron transport, succinate to ubiquinone response to oxidative stress Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6391 66052 Ensembl ENSG00000143252 ENSMUSG00000058076 UniProt Q99643 Q9CZB0 RefSeq (mRNA) NM_001035511 NM_001035512 NM_001035513 NM_001278172 NM_003001 NM_025321 RefSeq (protein) NP_001030588 NP_001030589 NP_001030590 NP_001265101 NP_002992 NP_079597 Location (UCSC) Chr 1: 161.31 – 161.36 Mb Chr 1: 170.95 – 170.98 Mb PubMed search [3] [4]
Wikidata
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Succinate dehydrogenase complex subunit C, also known as succinate dehydrogenase cytochrome b560 subunit, mitochondrial, is a protein that in humans is encoded by the SDHC gene.^[5] This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. There are several related pseudogenes for this gene on different chromosomes. Mutations in this gene have been associated with pheochromocytomas and paragangliomas. Alternatively spliced transcript variants have been described.^[6]