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| Eukaryotic peptide chain release factor GTP-binding subunit | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | Sus35 | ||||||
| Entrez | 851752 | ||||||
| HomoloGene | 68226 | ||||||
| RefSeq (mRNA) | NM_001180479.3 | ||||||
| RefSeq (Prot) | NP_010457.3 | ||||||
| UniProt | P05453 | ||||||
| Other data | |||||||
| Chromosome | IV: 0.81 - 0.81 Mb | ||||||
| |||||||
Sup35p is the Saccharomyces cerevisiae (a yeast) eukaryotic translation release factor. More specifically, it is the yeast eukaryotic release factor 3 (eRF3), which forms the translation termination complex with eRF1 (Sup45p in yeast). This complex recognizes and catalyzes the release of the nascent polypeptide chain when the ribosome encounters a stop codon. While eRF1 recognizes stop codons, eRF3 facilitates the release of the polypeptide chain through GTP hydrolysis.
Partial loss of function results in nonsense suppression, in which stop codons are ignored and proteins are abnormally synthesized with carboxyl terminal extensions. Complete loss of function is fatal.