Surface-enhanced Raman spectroscopy

Raman spectrum of liquid 2-mercaptoethanol (below) and SERS spectrum of 2-mercaptoethanol monolayer formed on roughened silver (above). Spectra are scaled and shifted for clarity. A difference in selection rules is visible: Some bands appear only in the bulk-phase Raman spectrum or only in the SERS spectrum.

Surface-enhanced Raman spectroscopy or surface-enhanced Raman scattering (SERS) is a surface-sensitive technique that enhances Raman scattering by molecules adsorbed on rough metal surfaces or by nanostructures such as plasmonic-magnetic silica nanotubes.[1] The enhancement factor can be as much as 1010 to 1011,[2][3] which means the technique may detect single molecules.[4][5]

  1. ^ Xu, X., Li, H., Hasan, D., Ruoff, R. S., Wang, A. X. and Fan, D. L. (2013), Near-Field Enhanced Plasmonic-Magnetic Bifunctional Nanotubes for Single Cell Bioanalysis. Adv. Funct. Mater.. doi:10.1002/adfm.201203822
  2. ^ Blackie, Evan J.; Le Ru, Eric C.; Etchegoin, Pablo G. (2009). "Single-Molecule Surface-Enhanced Raman Spectroscopy of Nonresonant Molecules". J. Am. Chem. Soc. 131 (40): 14466–14472. doi:10.1021/ja905319w. PMID 19807188.
  3. ^ Blackie, Evan J.; Le Ru, Eric C.; Meyer, Matthias; Etchegoin, Pablo G. (2007). "Surface Enhanced Raman Scattering Enhancement Factors: A Comprehensive Study". J. Phys. Chem. C. 111 (37): 13794–13803. CiteSeerX 10.1.1.556.4418. doi:10.1021/jp0687908.
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  5. ^ Kneipp, Katrin; Wang, Yang; Kneipp, Harald; Perelman, Lev T.; Itzkan, Irving; Dasari, Ramachandra R.; Feld, Michael S. (1997-03-03). "Single Molecule Detection Using Surface-Enhanced Raman Scattering (SERS)". Physical Review Letters. 78 (9): 1667–1670. doi:10.1103/PhysRevLett.78.1667.