Swiss-model

Swiss-model
TypeStructural bioinformatics tool
Licensefreeware, source code unavailable
Websiteswissmodel.expasy.org

Swiss-model (stylized as SWISS-MODEL) is a structural bioinformatics web-server dedicated to homology modeling of 3D protein structures.[1][2] As of 2024, homology modeling is the most accurate method to generate reliable three-dimensional protein structure models and is routinely used in many practical applications. Homology (or comparative) modelling methods make use of experimental protein structures (templates) to build models for evolutionary related proteins (targets).

Today, Swiss-model consists of three tightly integrated components: (1) The Swiss-model pipeline – a suite of software tools and databases for automated protein structure modelling,[1] (2) The Swiss-model Workspace – a web-based graphical user interface workbench,[2] (3) The Swiss-model Repository – a continuously updated database of homology models for a set of model organism proteomes of high biomedical interest.[3]

  1. ^ a b Schwede T, Kopp J, Guex N, Peitsch MC (2003). "Swiss-model: an automated protein homology-modeling server". Nucleic Acids Research. 31 (13): 3381–3385. doi:10.1093/nar/gkg520. PMC 168927. PMID 12824332.
  2. ^ a b Biasini M, Bienert S, Waterhouse A, Arnold K, Studer G, Schmidt T, Kiefer F, Cassarino TG, Bertoni M, Bordoli L, Schwede T (2014). "Swiss-model: modelling protein tertiary and quaternary structure using evolutionary information". Nucleic Acids Research. 42 (W1): 195–201. doi:10.1093/nar/gku340. PMC 4086089. PMID 24782522.
  3. ^ Bienert S, Waterhouse A, de Beer TA, Tauriello G, Studer G, Bordoli L, Schwede T (2017). "The Swiss-model Repository-new features and functionality". Nucleic Acids Research. 45 (D1): D313–D319. doi:10.1093/nar/gkw1132. PMC 5210589. PMID 27899672.