T-box transcription factor T

TBXT
Identifiers
Aliases	TBXT, T, brachyury homolog (mouse), SAVA, TFT, T brachyury transcription factor, T-box transcription factor T, T
External IDs	OMIM: 601397; MGI: 98472; HomoloGene: 2393; GeneCards: TBXT; OMA:TBXT - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	166,168,700 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	8,661,328 bp
RNA expression pattern
	Top expressed in
	gonad; ; testicle; ; oocyte; ; pars reticulata; ; renal medulla; ; synovial joint; ; secondary oocyte; ; human penis; ; external globus pallidus; ; synovial membrane;
	Top expressed in
	tail of embryo; ; paraxial mesoderm; ; primitive streak; ; notochord; ; mesoderm; ; embryonic organizer; ; epiblast; ; embryo; ; female urethra; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; chromatin; nucleus;
Biological process	somitogenesis; cellular response to retinoic acid; determination of heart left/right asymmetry; regulation of transcription, DNA-templated; SMAD protein signal transduction; regulation of transcription by RNA polymerase II; neural plate morphogenesis; bone morphogenesis; anatomical structure morphogenesis; heart morphogenesis; notochord development; signal transduction involved in regulation of gene expression; negative regulation of transcription by RNA polymerase II; BMP signaling pathway; transcription, DNA-templated; embryonic skeletal system development; vasculogenesis; multicellular organism development; reproductive process; neural tube closure; positive regulation of cell population proliferation; notochord; post-anal tail morphogenesis; canonical Wnt signaling pathway; mesoderm migration involved in gastrulation; mesoderm development; anterior/posterior axis specification, embryo; penetration of zona pellucida; primitive streak formation; signal transduction; anterior/posterior pattern specification; positive regulation of transcription by RNA polymerase II; negative regulation of DNA-binding transcription factor activity;
	Sources:Amigo / QuickGO
Orthologs
	6862
	20997
	ENSG00000164458
	ENSMUSG00000062327
	O15178
	P20293
	NM_001270484; NM_003181; NM_001366285; NM_001366286
	NM_009309
	NP_001257413; NP_003172; NP_001353214; NP_001353215
	NP_033335
	Wikidata
View/Edit Human	View/Edit Mouse

T-box transcription factor T, also known as Brachyury protein, is encoded for in humans and other apes by the TBXT gene.^[5]^[6]^[7] Brachyury functions as a transcription factor within the T-box family of genes.^[8] Brachyury homologs have been found in all bilaterian animals that have been screened, as well as the freshwater cnidarian Hydra.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164458 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000062327 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "TBXT - T-box transcription factor T - Homo sapiens (Human) - TBXT gene & protein". www.uniprot.org. Retrieved 21 May 2022.
^ Edwards YH, Putt W, Lekoape KM, Stott D, Fox M, Hopkinson DA, Sowden J (March 1996). "The human homolog T of the mouse T(Brachyury) gene; gene structure, cDNA sequence, and assignment to chromosome 6q27". Genome Research. 6 (3): 226–233. doi:10.1101/gr.6.3.226. PMID 8963900.
^ Xia, Bo; Zhang, Weimin; Zhao, Guisheng; Zhang, Xinru; Bai, Jiangshan; Brosh, Ran; Wudzinska, Aleksandra; Huang, Emily; Ashe, Hannah; Ellis, Gwen; Pour, Maayan; Zhao, Yu; Coelho, Camila; Zhu, Yinan; Miller, Alexander (28 February 2024). "On the genetic basis of tail-loss evolution in humans and apes". Nature. 626 (8001): 1042–1048. doi:10.1038/s41586-024-07095-8. ISSN 1476-4687. PMC 10901737.
^ ^a ^b Scholz CB, Technau U (January 2003). "The ancestral role of Brachyury: expression of NemBra1 in the basal cnidarian Nematostella vectensis (Anthozoa)". Development Genes and Evolution. 212 (12): 563–570. doi:10.1007/s00427-002-0272-x. PMID 12536320. S2CID 25311702.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164458 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000062327 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[uniprot-5] "TBXT - T-box transcription factor T - Homo sapiens (Human) - TBXT gene & protein". www.uniprot.org. Retrieved 21 May 2022.

[pmid8963900-6] Edwards YH, Putt W, Lekoape KM, Stott D, Fox M, Hopkinson DA, Sowden J (March 1996). "The human homolog T of the mouse T(Brachyury) gene; gene structure, cDNA sequence, and assignment to chromosome 6q27". Genome Research. 6 (3): 226–233. doi:10.1101/gr.6.3.226. PMID 8963900.

[7] Xia, Bo; Zhang, Weimin; Zhao, Guisheng; Zhang, Xinru; Bai, Jiangshan; Brosh, Ran; Wudzinska, Aleksandra; Huang, Emily; Ashe, Hannah; Ellis, Gwen; Pour, Maayan; Zhao, Yu; Coelho, Camila; Zhu, Yinan; Miller, Alexander (28 February 2024). "On the genetic basis of tail-loss evolution in humans and apes". Nature. 626 (8001): 1042–1048. doi:10.1038/s41586-024-07095-8. ISSN 1476-4687. PMC 10901737.

[Scholz2002-8] Scholz CB, Technau U (January 2003). "The ancestral role of Brachyury: expression of NemBra1 in the basal cnidarian Nematostella vectensis (Anthozoa)". Development Genes and Evolution. 212 (12): 563–570. doi:10.1007/s00427-002-0272-x. PMID 12536320. S2CID 25311702.

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