TAAR2

TAAR2
Identifiers
Aliases	TAAR2, GPR58, taR-2, trace amine associated receptor 2, trace amine associated receptor 2 (gene/pseudogene)
External IDs	OMIM: 604849; MGI: 2685071; HomoloGene: 110760; GeneCards: TAAR2; OMA:TAAR2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	132,624,275 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	23,817,481 bp
RNA expression pattern
	Top expressed in
	testicle; ; tibialis anterior muscle; ; gonad; ; deltoid muscle; ; lower lobe of lung; ; left testis; ; right testis;
	Top expressed in
	embryo; ; morula; ; nose; ; nasal septum; ; ganglion; ; Grüneberg ganglion; ; stomach;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; G protein-coupled receptor activity; trace-amine receptor activity;
Cellular component	plasma membrane; membrane; integral component of membrane;
Biological process	signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	9287
	209512
	ENSG00000146378
	ENSMUSG00000059763
	Q9P1P5
	Q5QD17
	NM_001033080; NM_014626
	NM_001007266
	NP_001028252; NP_055441
	NP_001007267
	Wikidata
View/Edit Human	View/Edit Mouse

Trace amine-associated receptor 2 (TAAR2), formerly known as G protein-coupled receptor 58 (GPR58), is a protein that in humans is encoded by the TAAR2 gene.^[5]^[6]^[7]^[8] TAAR2 is co-expressed with G_α proteins;^[8] however, as of February 2017,^[update] its signal transduction mechanisms have not been determined.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000146378 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000059763 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lee DK, Lynch KR, Nguyen T, Im DS, Cheng R, Saldivia VR, et al. (February 2000). "Cloning and characterization of additional members of the G protein-coupled receptor family". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1490 (3): 311–23. doi:10.1016/s0167-4781(99)00241-9. PMID 10684976.
^ Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (March 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics. 85 (3): 372–85. doi:10.1016/j.ygeno.2004.11.010. PMID 15718104.
^ "Entrez Gene: TAAR2 trace amine associated receptor 2".
^ ^a ^b ^c Davenport AP, Alexander S, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga C, Battey J, Benya RV, Jensen RT, Karnik S, Kostenis E, Spindel E, Storjohann L, Tirupula K, Bonner TI, Neubig R, Pin JP, Spedding M, Harmar A (25 June 2015). "TAAR2". IUPHAR/BPS Guide to PHARMACOLOGY. International Union of Basic and Clinical Pharmacology. Retrieved 22 February 2017.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000146378 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059763 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10684976-5] Lee DK, Lynch KR, Nguyen T, Im DS, Cheng R, Saldivia VR, et al. (February 2000). "Cloning and characterization of additional members of the G protein-coupled receptor family". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1490 (3): 311–23. doi:10.1016/s0167-4781(99)00241-9. PMID 10684976.

[pmid15718104-6] Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (March 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics. 85 (3): 372–85. doi:10.1016/j.ygeno.2004.11.010. PMID 15718104.

[entrez-7] "Entrez Gene: TAAR2 trace amine associated receptor 2".

[IUPHAR_TAAR2-8] Davenport AP, Alexander S, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga C, Battey J, Benya RV, Jensen RT, Karnik S, Kostenis E, Spindel E, Storjohann L, Tirupula K, Bonner TI, Neubig R, Pin JP, Spedding M, Harmar A (25 June 2015). "TAAR2". IUPHAR/BPS Guide to PHARMACOLOGY. International Union of Basic and Clinical Pharmacology. Retrieved 22 February 2017.

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