TAAR3

TAAR3P
Identifiers
AliasesTAAR3P, GPR57, GPR58, TAAR2, TAAR3, trace amine associated receptor 3 (gene/pseudogene), trace amine associated receptor 3, pseudogene
External IDsGeneCards: TAAR3P; OMA:TAAR3P - orthologs
Orthologs
SpeciesHumanMouse
Entrez

9288

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Ensembl

ENSG00000179073

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UniProt

n
a

n/a

RefSeq (mRNA)

NM_014627

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RefSeq (protein)

n/a

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Location (UCSC)Chr 6: 132.61 – 132.61 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Putative trace amine-associated receptor 3 (TAAR3) is a human pseudogene with the gene symbol TAAR3P.[3][4][5][6] In other species such as mice, TAAR3 is a functional protein-coding gene that encodes a trace amine-associated receptor protein.

Isobutylamine is a known ligand of TAAR3 in mice associated with sexual behaviour in male mice.[7]

Isopentylamine was identified as a ligand for murine TAAR3 eliciting aversive behavior.[8]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000179073 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ HGNC:4513 Retrieved 28 November 2019
  4. ^ Lee DK, Lynch KR, Nguyen T, Im DS, Cheng R, Saldivia VR, et al. (February 2000). "Cloning and characterization of additional members of the G protein-coupled receptor family". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1490 (3): 311–23. doi:10.1016/s0167-4781(99)00241-9. PMID 10684976.
  5. ^ Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (March 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics. 85 (3): 372–85. doi:10.1016/j.ygeno.2004.11.010. PMID 15718104.
  6. ^ "Entrez Gene: TAAR3 trace amine associated receptor 3".
  7. ^ Harmeier A, Meyer CA, Staempfli A, Casagrande F, Petrinovic MM, Zhang YP, et al. (2018). "How Female Mice Attract Males: A Urinary Volatile Amine Activates a Trace Amine-Associated Receptor That Induces Male Sexual Interest". Frontiers in Pharmacology. 9: 924. doi:10.3389/fphar.2018.00924. PMC 6104183. PMID 30158871.
  8. ^ Liberles SD (October 2015). "Trace amine-associated receptors: ligands, neural circuits, and behaviors". Current Opinion in Neurobiology. 34: 1–7. doi:10.1016/j.conb.2015.01.001. PMC 4508243. PMID 25616211.