TAAR9

TAAR9
Identifiers
AliasesTAAR9, TA3, TAR3, TAR9, TRAR3, trace amine associated receptor 9 (gene/pseudogene), trace amine associated receptor 9
External IDsOMIM: 608282; MGI: 3527454; HomoloGene: 65286; GeneCards: TAAR9; OMA:TAAR9 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

134860

503558

Ensembl

ENSG00000237110

ENSMUSG00000037424

UniProt

Q96RI9

Q5QD04

RefSeq (mRNA)

NM_175057

NM_001010831

RefSeq (protein)

NP_778227

NP_001010831

Location (UCSC)Chr 6: 132.54 – 132.54 MbChr 10: 23.98 – 23.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Trace amine-associated receptor 9 is a protein that in humans is encoded by the TAAR9 gene.[5][6]

TAAR9 is a member of a large family of rhodopsin G protein–coupled receptors (GPCRs, or GPRs). GPCRs contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM][6] N-Methyl piperidine is a ligand of TAAR9 associated with aversive behavior in mice. N,N-dimethylcyclohexylamine is an additional binding agonist that also activaes TAAR7 variants.[7][8]

TAAR9 gene deletion in rats leads to significantly decreased low-density lipoprotein cholesterol levels in the blood.[9]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000237110 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037424 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (March 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics. 85 (3): 372–85. doi:10.1016/j.ygeno.2004.11.010. PMID 15718104.
  6. ^ a b "Entrez Gene: TAAR9 trace amine associated receptor 9".
  7. ^ Ferrero DM, Wacker D, Roque MA, Baldwin MW, Stevens RC, Liberles SD (July 2012). "Agonists for 13 trace amine-associated receptors provide insight into the molecular basis of odor selectivity". ACS Chemical Biology. 7 (7): 1184–9. doi:10.1021/cb300111e. PMC 3401279. PMID 22545963.
  8. ^ Liberles SD (October 2015). "Trace amine-associated receptors: ligands, neural circuits, and behaviors". Current Opinion in Neurobiology. 34: 1–7. doi:10.1016/j.conb.2015.01.001. PMC 4508243. PMID 25616211.
  9. ^ Murtazina RZ, Zhukov IS, Korenkova OM, Popova EA, Kuvarzin SR, Efimova EV, et al. (March 2021). "Genetic Deletion of Trace-Amine Associated Receptor 9 (TAAR9) in Rats Leads to Decreased Blood Cholesterol Levels". International Journal of Molecular Sciences. 22 (6): 2942. doi:10.3390/ijms22062942. PMC 7998418. PMID 33799339.