TANK-binding kinase 1

TBK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4EFO, 4EUT, 4EUU, 4IM0, 4IM2, 4IM3, 4IW0, 4IWO, 4IWP, 4IWQ
Identifiers
Aliases	TBK1, Tbk1, 1200008B05Rik, AI462036, AW048562, NAK, T2K, FTDALS4, TANK binding kinase 1, IIAE8
External IDs	OMIM: 604834; MGI: 1929658; HomoloGene: 22742; GeneCards: TBK1; OMA:TBK1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	64,502,114 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	121,422,692 bp
RNA expression pattern
	Top expressed in
	epithelium of colon; ; Achilles tendon; ; lateral nuclear group of thalamus; ; secondary oocyte; ; sperm; ; monocyte; ; sural nerve; ; ventricular zone; ; tonsil; ; bone marrow cells;
	Top expressed in
	Paneth cell; ; facial motor nucleus; ; condyle; ; Epithelium of choroid plexus; ; fossa; ; substantia nigra; ; conjunctival fornix; ; iris; ; stroma of bone marrow; ; vestibular membrane of cochlear duct;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; kinase activity; protein serine/threonine kinase activity; phosphoprotein binding; protein binding; nucleic acid binding; ATP binding; protein kinase activity; identical protein binding; protein phosphatase binding;
Cellular component	cytoplasm; cytosol; endosome membrane; nucleoplasm; aggresome;
Biological process	phosphorylation; positive regulation of interferon-alpha production; immune system process; response to virus; positive regulation of xenophagy; negative regulation of gene expression; positive regulation of peptidyl-serine phosphorylation; TRIF-dependent toll-like receptor signaling pathway; type I interferon production; defense response to virus; peptidyl-serine phosphorylation; regulation of neuron death; activation of innate immune response; positive regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of type I interferon production; innate immune response; viral process; inflammatory response; I-kappaB kinase/NF-kappaB signaling; positive regulation of type I interferon production; positive regulation of transcription by RNA polymerase II; dendritic cell proliferation; defense response to Gram-positive bacterium; positive regulation of interferon-beta production; regulation of type I interferon production; positive regulation of macroautophagy; peptidyl-threonine phosphorylation; protein phosphorylation; cellular response to cytokine stimulus; regulation of gene expression; regulation of cellular metabolic process; positive regulation of type I interferon-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	29110
	56480
	ENSG00000183735
	ENSMUSG00000020115
	Q9UHD2
	Q9WUN2
	NM_013254
	NM_019786
	NP_037386
	NP_062760
	Wikidata
View/Edit Human	View/Edit Mouse

TBK1 (TANK-binding kinase 1) is an enzyme with kinase activity. Specifically, it is a serine / threonine protein kinase.^[5] It is encoded by the TBK1 gene in humans.^[6] This kinase is mainly known for its role in innate immunity antiviral response. However, TBK1 also regulates cell proliferation, apoptosis, autophagy, and anti-tumor immunity.^[5] Insufficient regulation of TBK1 activity leads to autoimmune, neurodegenerative diseases or tumorigenesis.^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183735 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020115 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Helgason E, Phung QT, Dueber EC (April 2013). "Recent insights into the complexity of Tank-binding kinase 1 signaling networks: the emerging role of cellular localization in the activation and substrate specificity of TBK1". FEBS Letters. 587 (8): 1230–1237. doi:10.1016/j.febslet.2013.01.059. PMID 23395801.
^ "Entrez Gene: TBK1 TANK-binding kinase 1".
^ Louis C, Burns C, Wicks I (2018-03-06). "TANK-Binding Kinase 1-Dependent Responses in Health and Autoimmunity". Frontiers in Immunology. 9: 434. doi:10.3389/fimmu.2018.00434. PMC 5845716. PMID 29559975.
^ Cruz VH, Brekken RA (March 2018). "Assessment of TANK-binding kinase 1 as a therapeutic target in cancer". Journal of Cell Communication and Signaling. 12 (1): 83–90. doi:10.1007/s12079-017-0438-y. PMC 5842199. PMID 29218456.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183735 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020115 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[:0-5] Helgason E, Phung QT, Dueber EC (April 2013). "Recent insights into the complexity of Tank-binding kinase 1 signaling networks: the emerging role of cellular localization in the activation and substrate specificity of TBK1". FEBS Letters. 587 (8): 1230–1237. doi:10.1016/j.febslet.2013.01.059. PMID 23395801.

[entrez-6] "Entrez Gene: TBK1 TANK-binding kinase 1".

[:1-7] Louis C, Burns C, Wicks I (2018-03-06). "TANK-Binding Kinase 1-Dependent Responses in Health and Autoimmunity". Frontiers in Immunology. 9: 434. doi:10.3389/fimmu.2018.00434. PMC 5845716. PMID 29559975.

[:3-8] Cruz VH, Brekken RA (March 2018). "Assessment of TANK-binding kinase 1 as a therapeutic target in cancer". Journal of Cell Communication and Signaling. 12 (1): 83–90. doi:10.1007/s12079-017-0438-y. PMC 5842199. PMID 29218456.

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