TAOK1

TAOK1
Identifiers
Aliases	TAOK1, KFC-B, MAP3K16, MARKK, PSK-2, PSK2, TAO1, hKFC-B, hTAO kinase 1, DDIB
External IDs	OMIM: 610266; MGI: 1914490; HomoloGene: 27041; GeneCards: TAOK1; OMA:TAOK1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	29,551,903 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	77,498,641 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; globus pallidus; ; internal globus pallidus; ; ventral tegmental area; ; subthalamic nucleus; ; sural nerve; ; pars compacta; ; inferior ganglion of vagus nerve; ; pons; ; external globus pallidus;
	Top expressed in
	ventromedial nucleus; ; lateral septal nucleus; ; amygdala; ; lateral geniculate nucleus; ; olfactory tubercle; ; anterior amygdaloid area; ; mammillary body; ; habenula; ; inferior colliculi; ; globus pallidus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; MAP kinase kinase kinase activity; alpha-tubulin binding; protein serine/threonine kinase activator activity; tau protein binding; beta-tubulin binding; tau-protein kinase activity;
Cellular component	cytoplasm; cytosol; extracellular exosome; nucleus; microtubule cytoskeleton; perinuclear region of cytoplasm;
Biological process	phosphorylation; execution phase of apoptosis; positive regulation of JNK cascade; cellular response to DNA damage stimulus; protein phosphorylation; spindle checkpoint signaling; regulation of cytoskeleton organization; DNA repair; positive regulation of stress-activated MAPK cascade; apoptotic process; sister chromatid cohesion; MAPK cascade; regulation of mitotic cell cycle; nervous system development; regulation of apoptotic process; microtubule cytoskeleton organization; negative regulation of microtubule depolymerization; mitotic G2 DNA damage checkpoint signaling; signal transduction; stress-activated protein kinase signaling cascade; activation of protein kinase activity; regulation of actin cytoskeleton organization; protein autophosphorylation; neuron cellular homeostasis; regulation of microtubule cytoskeleton organization; positive regulation of protein acetylation;
	Sources:Amigo / QuickGO
Orthologs
	57551
	216965
	ENSG00000160551
	ENSMUSG00000017291
	Q7L7X3
	Q5F2E8
	NM_020791; NM_025142
	NM_144825; NM_001364133; NM_001364134
	NP_065842; NP_079418
	NP_659074; NP_001351062; NP_001351063
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase TAO1 is an enzyme that in humans is encoded by the TAOK1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160551 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000017291 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (Apr 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
^ Timm T, Li XY, Biernat J, Jiao J, Mandelkow E, Vandekerckhove J, Mandelkow EM (Sep 2003). "MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1". EMBO J. 22 (19): 5090–101. doi:10.1093/emboj/cdg447. PMC 204455. PMID 14517247.
^ "Entrez Gene: TAOK1 TAO kinase 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160551 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000017291 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10718198-5] Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (Apr 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.

[pmid14517247-6] Timm T, Li XY, Biernat J, Jiao J, Mandelkow E, Vandekerckhove J, Mandelkow EM (Sep 2003). "MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1". EMBO J. 22 (19): 5090–101. doi:10.1093/emboj/cdg447. PMC 204455. PMID 14517247.

[entrez-7] "Entrez Gene: TAOK1 TAO kinase 1".

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