TAR DNA-binding protein 43

TARDBP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WF0, 2CQG, 4BS2, 4IUF, 4Y0F, 2N4P, 2N2C, 4Y00, 2N4G, 2N4H, 2N3X
Identifiers
Aliases	TARDBP, ALS10, TDP-43, TAR DNA binding protein
External IDs	OMIM: 605078; MGI: 2387629; HomoloGene: 7221; GeneCards: TARDBP; OMA:TARDBP - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.22 Start 11,012,344 bp[1] End 11,030,528 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 E2 Start 148,696,839 bp[2] End 148,711,476 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte ventricular zone ganglionic eminence tibia rectum epithelium of nasopharynx left ovary left lobe of thyroid gland tibial nerve visceral pleura Top expressed in primitive streak spermatocyte ventricular zone neural layer of retina otic placode abdominal wall limb bud epiblast tail of embryo otic vesicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity mRNA 3'-UTR binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding identical protein binding RNA binding nucleic acid binding double-stranded DNA binding single-stranded RNA binding sequence-specific double-stranded DNA binding Cellular component cytoplasm nuclear speck nucleoplasm interchromatin granule perichromatin fibrils nucleus ribonucleoprotein complex cytoplasmic stress granule Biological process negative regulation of protein phosphorylation regulation of transcription, DNA-templated mRNA processing negative regulation of gene expression response to endoplasmic reticulum stress transcription, DNA-templated regulation of cell cycle negative regulation by host of viral transcription RNA splicing nuclear inner membrane organization 3'-UTR-mediated mRNA stabilization positive regulation of transcription by RNA polymerase II positive regulation of insulin secretion transcription by RNA polymerase II regulation of apoptotic process positive regulation of protein import into nucleus regulation of protein stability regulation of circadian rhythm rhythmic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23435 230908 Ensembl ENSG00000120948 ENSMUSG00000041459 UniProt Q13148 Q921F2 RefSeq (mRNA) NM_007375 NM_001003898 NM_001003899 NM_001008545 NM_001008546 NM_145556 NM_001305425 RefSeq (protein) NP_031401 NP_031401.1 NP_001003898 NP_001003899 NP_001008545 NP_001008546 NP_001292354 NP_663531 Location (UCSC) Chr 1: 11.01 – 11.03 Mb Chr 4: 148.7 – 148.71 Mb PubMed search [3] [4]
Wikidata
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Transactive response DNA binding protein 43 kDa (TAR DNA-binding protein 43 or TDP-43) is a protein that in humans is encoded by the TARDBP gene.^[5]