TAS1R2

TAS1R2
Identifiers
Aliases	TAS1R2, GPR71, T1R2, TR2, taste 1 receptor member 2
External IDs	OMIM: 606226; MGI: 1933546; HomoloGene: 75323; GeneCards: TAS1R2; OMA:TAS1R2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	18,859,682 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	139,397,591 bp
RNA expression pattern
	Top expressed in
	skin of leg; ; skin of abdomen; ; olfactory zone of nasal mucosa;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; taste receptor activity; protein heterodimerization activity; sweet taste receptor activity; signaling receptor activity;
Cellular component	integral component of membrane; receptor complex; plasma membrane; sweet taste receptor complex; membrane; integral component of plasma membrane;
Biological process	positive regulation of cytokinesis; sensory perception of taste; sensory perception of sweet taste; detection of chemical stimulus involved in sensory perception of sweet taste; signal transduction; response to stimulus; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	80834
	83770
	ENSG00000179002
	ENSMUSG00000028738
	Q8TE23
	Q925I4
	NM_152232
	NM_031873
	NP_689418
	NP_114079
	Wikidata
View/Edit Human	View/Edit Mouse

T1R2 - Taste receptor type 1 member 2 is a protein that in humans is encoded by the TAS1R2 gene.^[5]

The sweet taste receptor is predominantly formed as a dimer of T1R2 and T1R3 by which different organisms sense this taste. In songbirds, however, the T1R2 monomer does not exist, and they sense the sweet taste through the umami taste receptor (T1R1 and T1R3) as a result of an evolutionary change that it has undergone.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000179002 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028738 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: TAS1R2 taste receptor, type 1, member 2".
^ Toda Y, Ko MC, Liang Q, Miller ET, Rico-Guevara A, Nakagita T, et al. (July 2021). "Early origin of sweet perception in the songbird radiation". Science. 373 (6551): 226–231. Bibcode:2021Sci...373..226T. doi:10.1126/science.abf6505. PMID 34244416. S2CID 235769720.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000179002 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028738 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: TAS1R2 taste receptor, type 1, member 2".

[6] Toda Y, Ko MC, Liang Q, Miller ET, Rico-Guevara A, Nakagita T, et al. (July 2021). "Early origin of sweet perception in the songbird radiation". Science. 373 (6551): 226–231. Bibcode:2021Sci...373..226T. doi:10.1126/science.abf6505. PMID 34244416. S2CID 235769720.

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