TAS1R3

TAS1R3
Identifiers
Aliases	TAS1R3, T1R3, taste 1 receptor member 3
External IDs	OMIM: 605865; MGI: 1933547; HomoloGene: 12890; GeneCards: TAS1R3; OMA:TAS1R3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	1,335,314 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	155,947,819 bp
RNA expression pattern
	Top expressed in
	bone marrow cells; ; mucosa of transverse colon; ; spleen; ; tonsil; ; duodenum; ; lymph node; ; ganglionic eminence; ; muscle of thigh; ; sural nerve; ; gastrocnemius muscle;
	Top expressed in
	ascending aorta; ; aortic valve; ; morula; ; granulocyte; ; tongue; ; tail of embryo; ; supraoptic nucleus; ; ganglionic eminence; ; esophagus; ; jejunum;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; taste receptor activity; protein heterodimerization activity; sweet taste receptor activity; signaling receptor activity;
Cellular component	integral component of membrane; plasma membrane; sweet taste receptor complex; membrane; integral component of plasma membrane;
Biological process	sensory perception of taste; sensory perception of sweet taste; sensory perception of umami taste; detection of chemical stimulus involved in sensory perception of sweet taste; signal transduction; response to stimulus; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	83756
	83771
	ENSG00000169962
	ENSMUSG00000029072
	Q7RTX0
	Q925D8
	NM_152228
	NM_031872
	NP_689414
	NP_114078
	Wikidata
View/Edit Human	View/Edit Mouse

Taste receptor type 1 member 3 is a protein that in humans is encoded by the TAS1R3 gene.^[5]^[6] The TAS1R3 gene encodes the human homolog of mouse Sac taste receptor, a major determinant of differences between sweet-sensitive and -insensitive mouse strains in their responsiveness to sucrose, saccharin, and other sweeteners.^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169962 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029072 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Montmayeur JP, Liberles SD, Matsunami H, Buck LB (Apr 2001). "A candidate taste receptor gene near a sweet taste locus". Nat Neurosci. 4 (5): 492–8. doi:10.1038/87440. PMID 11319557. S2CID 21010650.
^ ^a ^b "Entrez Gene: TAS1R3 taste receptor, type 1, member 3".
^ Bachmanov AA, Li X, Reed DR, Ohmen JD, Li S, Chen Z, et al. (September 2001). "Positional cloning of the mouse saccharin preference (Sac) locus". Chemical Senses. 26 (7): 925–933. doi:10.1093/chemse/26.7.925. PMC 3644801. PMID 11555487.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169962 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029072 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11319557-5] Montmayeur JP, Liberles SD, Matsunami H, Buck LB (Apr 2001). "A candidate taste receptor gene near a sweet taste locus". Nat Neurosci. 4 (5): 492–8. doi:10.1038/87440. PMID 11319557. S2CID 21010650.

[entrez-6] "Entrez Gene: TAS1R3 taste receptor, type 1, member 3".

[7] Bachmanov AA, Li X, Reed DR, Ohmen JD, Li S, Chen Z, et al. (September 2001). "Positional cloning of the mouse saccharin preference (Sac) locus". Chemical Senses. 26 (7): 925–933. doi:10.1093/chemse/26.7.925. PMC 3644801. PMID 11555487.

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