TAS2R1

TAS2R1
Identifiers
Aliases	TAS2R1, T2R1, TRB7, taste 2 receptor member 1
External IDs	OMIM: 604796; MGI: 2681253; HomoloGene: 10480; GeneCards: TAS2R1; OMA:TAS2R1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	9,712,378 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	32,178,440 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; stromal cell of endometrium; ; epithelium of colon; ; placenta; ; caudate nucleus; ; putamen; ; nucleus accumbens; ; hippocampal formation; ; prefrontal cortex;
	Top expressed in
	proximal tubule; ; right kidney; ; genital tubercle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; taste receptor activity; bitter taste receptor activity;
Cellular component	plasma membrane; membrane; integral component of membrane;
Biological process	G protein-coupled receptor signaling pathway; detection of chemical stimulus involved in sensory perception of bitter taste; signal transduction; response to stimulus; sensory perception of taste;
	Sources:Amigo / QuickGO
Orthologs
	50834
	57254
	ENSG00000169777
	ENSMUSG00000045267
	Q9NYW7
	Q9JKT2
	NM_019599; NM_001386348
	NM_020503
	NP_062545
	NP_065249
	Wikidata
View/Edit Human	View/Edit Mouse

Taste receptor type 2 member 1 (TAS2R1/T2R1) is a protein that in humans is encoded by the TAS2R1 gene.^[5]^[6]^[7] It belongs to the G protein-coupled receptor (GPCR) family and is related to class A-like GPCRs, they contain 7 transmembrane helix bundles and short N-terminus loop.^[8] Furthermore, TAS2R1 is member of the 25 known human bitter taste receptors, which enable the perception of bitter taste in the mouth cavity. Increasing evidence indicates a functional role of TAS2Rs in extra-oral tissues.^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169777 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045267 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (March 2000). "A novel family of mammalian taste receptors". Cell. 100 (6): 693–702. doi:10.1016/S0092-8674(00)80705-9. PMID 10761934. S2CID 14604586.
^ Matsunami H, Montmayeur JP, Buck LB (April 2000). "A family of candidate taste receptors in human and mouse". Nature. 404 (6778): 601–604. Bibcode:2000Natur.404..601M. doi:10.1038/35007072. PMID 10766242. S2CID 4336913.
^ "Entrez Gene: TAS2R1 taste receptor, type 2, member 1".
^ Di Pizio A, Levit A, Slutzki M, Behrens M, Karaman R, Niv MY (2016). "Comparing Class a GPCRS to bitter taste receptors". Comparing Class A GPCRs to bitter taste receptors: Structural motifs, ligand interactions and agonist-to-antagonist ratios. Methods in Cell Biology. Vol. 132. Elsevier. pp. 401–427. doi:10.1016/bs.mcb.2015.10.005. ISBN 978-0-12-803595-5. PMID 26928553.
^ Lu P, Zhang CH, Lifshitz LM, ZhuGe R (February 2017). "Extraoral bitter taste receptors in health and disease". The Journal of General Physiology. 149 (2): 181–197. doi:10.1085/jgp.201611637. PMC 5299619. PMID 28053191.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169777 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000045267 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10761934-5] Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (March 2000). "A novel family of mammalian taste receptors". Cell. 100 (6): 693–702. doi:10.1016/S0092-8674(00)80705-9. PMID 10761934. S2CID 14604586.

[pmid10766242-6] Matsunami H, Montmayeur JP, Buck LB (April 2000). "A family of candidate taste receptors in human and mouse". Nature. 404 (6778): 601–604. Bibcode:2000Natur.404..601M. doi:10.1038/35007072. PMID 10766242. S2CID 4336913.

[entrez-7] "Entrez Gene: TAS2R1 taste receptor, type 2, member 1".

[Di_Pizio_2016-8] Di Pizio A, Levit A, Slutzki M, Behrens M, Karaman R, Niv MY (2016). "Comparing Class a GPCRS to bitter taste receptors". Comparing Class A GPCRs to bitter taste receptors: Structural motifs, ligand interactions and agonist-to-antagonist ratios. Methods in Cell Biology. Vol. 132. Elsevier. pp. 401–427. doi:10.1016/bs.mcb.2015.10.005. ISBN 978-0-12-803595-5. PMID 26928553.

[Lu_2017-9] Lu P, Zhang CH, Lifshitz LM, ZhuGe R (February 2017). "Extraoral bitter taste receptors in health and disease". The Journal of General Physiology. 149 (2): 181–197. doi:10.1085/jgp.201611637. PMC 5299619. PMID 28053191.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]