TAS2R14

TAS2R14
Identifiers
Aliases	TAS2R14, T2R14, TRB1, taste 2 receptor member 14
External IDs	OMIM: 604790; MGI: 2681298; HomoloGene: 87013; GeneCards: TAS2R14; OMA:TAS2R14 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	11,171,573 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	133,032,779 bp
RNA expression pattern
	Top expressed in
	testicle; ; corpus callosum; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; right ovary; ; C1 segment; ; left ovary; ; endometrium; ; gastric mucosa; ; body of uterus;
	Top expressed in
	spermatid;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; taste receptor activity; bitter taste receptor activity;
Cellular component	plasma membrane; membrane; integral component of membrane;
Biological process	detection of chemical stimulus involved in sensory perception of bitter taste; signal transduction; response to stimulus; sensory perception of taste; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	50840
	387616
	ENSG00000212127; ENSG00000261984; ENSG00000276541
	ENSMUSG00000071147
	Q9NYV8
	Q7TQA4
	NM_023922
	NM_021562
	NP_076411
	NP_067537
	Wikidata
View/Edit Human	View/Edit Mouse

Taste receptor type 2 member 14 is a protein that in humans is encoded by the TAS2R14 gene.^[5]^[6]^[7]

Taste receptors for bitter substances (T2Rs/TAS2Rs) belong to the family of G-protein coupled receptors and are related to class A-like GPCRs. There are 25 known T2Rs in humans responsible for bitter taste perception.^[8]

Bitter taste receptor hTAS2R14 is one of the human bitter taste receptors, recognizing an enormous variety of structurally different molecules, including natural and synthetic bitter compounds.^[9]

^ ^a ^b ^c ENSG00000261984, ENSG00000276541 GRCh38: Ensembl release 89: ENSG00000212127, ENSG00000261984, ENSG00000276541 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000071147 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (March 2000). "A novel family of mammalian taste receptors". Cell. 100 (6): 693–702. doi:10.1016/S0092-8674(00)80705-9. PMID 10761934. S2CID 14604586.
^ Matsunami H, Montmayeur JP, Buck LB (April 2000). "A family of candidate taste receptors in human and mouse". Nature. 404 (6778): 601–604. Bibcode:2000Natur.404..601M. doi:10.1038/35007072. PMID 10766242. S2CID 4336913.
^ "Entrez Gene: TAS2R14 taste receptor, type 2, member 14".
^ Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, Bufe B, et al. (February 2010). "The molecular receptive ranges of human TAS2R bitter taste receptors". Chemical Senses. 35 (2): 157–170. doi:10.1093/chemse/bjp092. PMID 20022913.
^ Di Pizio A, Niv MY (July 2015). "Promiscuity and selectivity of bitter molecules and their receptors". Bioorganic & Medicinal Chemistry. 23 (14): 4082–4091. doi:10.1016/j.bmc.2015.04.025. PMID 25934224.

[refGRCh38Ensembl-1] ENSG00000261984, ENSG00000276541 GRCh38: Ensembl release 89: ENSG00000212127, ENSG00000261984, ENSG00000276541 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000071147 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10761934-5] Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (March 2000). "A novel family of mammalian taste receptors". Cell. 100 (6): 693–702. doi:10.1016/S0092-8674(00)80705-9. PMID 10761934. S2CID 14604586.

[pmid10766242-6] Matsunami H, Montmayeur JP, Buck LB (April 2000). "A family of candidate taste receptors in human and mouse". Nature. 404 (6778): 601–604. Bibcode:2000Natur.404..601M. doi:10.1038/35007072. PMID 10766242. S2CID 4336913.

[entrez-7] "Entrez Gene: TAS2R14 taste receptor, type 2, member 14".

[8] Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, Bufe B, et al. (February 2010). "The molecular receptive ranges of human TAS2R bitter taste receptors". Chemical Senses. 35 (2): 157–170. doi:10.1093/chemse/bjp092. PMID 20022913.

[:0-9] Di Pizio A, Niv MY (July 2015). "Promiscuity and selectivity of bitter molecules and their receptors". Bioorganic & Medicinal Chemistry. 23 (14): 4082–4091. doi:10.1016/j.bmc.2015.04.025. PMID 25934224.

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