TAS2R16

TAS2R16
Identifiers
Aliases	TAS2R16, T2R16, taste 2 receptor member 16, BGLPT
External IDs	OMIM: 604867; MGI: 2681247; HomoloGene: 9660; GeneCards: TAS2R16; OMA:TAS2R16 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	122,995,700 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	23,970,059 bp
RNA expression pattern
	Top expressed in
	tibialis anterior muscle; ; gonad; ; deltoid muscle; ; hypothalamus;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; protein binding; signal transducer activity; bitter taste receptor activity;
Cellular component	trans-Golgi network; plasma membrane; endoplasmic reticulum; external side of plasma membrane; membrane; integral component of membrane;
Biological process	detection of chemical stimulus involved in sensory perception of bitter taste; signal transduction; response to stimulus; sensory perception of taste; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	50833
	387347
	ENSG00000128519
	ENSMUSG00000043865
	Q9NYV7
	P59529
	NM_016945
	NM_207022
	NP_058641
	NP_996905
	Wikidata
View/Edit Human	View/Edit Mouse

TAS2R16 (taste receptor, type 2, member 16) is a bitter taste receptor and one of the 25 TAS2Rs. TAS2Rs are receptors that belong to the G-protein-coupled receptors (GPCRs) family. These receptors detect various bitter substances found in nature as agonists, and get stimulated. TAS2R16 receptor is mainly expressed within taste buds present on the surface of the tongue and palate epithelium.^[5] TAS2R16 is activated by bitter β-glucopyranosides (such as salicin)^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000128519 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000043865 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Itoigawa A, Hayakawa T, Suzuki-Hashido N, Imai H (June 2019). "A natural point mutation in the bitter taste receptor TAS2R16 causes inverse agonism of arbutin in lemur gustation". Proceedings. Biological Sciences. 286 (1904): 20190884. doi:10.1098/rspb.2019.0884. PMC 6571456. PMID 31161904.
^ Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (November 2002). "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides". Nature Genetics. 32 (3): 397–401. doi:10.1038/ng1014. PMID 12379855. S2CID 20426192.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000128519 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000043865 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[A_natural_point_mutation_in_the_bit-5] Itoigawa A, Hayakawa T, Suzuki-Hashido N, Imai H (June 2019). "A natural point mutation in the bitter taste receptor TAS2R16 causes inverse agonism of arbutin in lemur gustation". Proceedings. Biological Sciences. 286 (1904): 20190884. doi:10.1098/rspb.2019.0884. PMC 6571456. PMID 31161904.

[6] Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (November 2002). "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides". Nature Genetics. 32 (3): 397–401. doi:10.1038/ng1014. PMID 12379855. S2CID 20426192.

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