TAS2R38

TAS2R38
Identifiers
Aliases	TAS2R38, PTC, T2R38, T2R61, taste 2 receptor member 38, THIOT
External IDs	OMIM: 607751; MGI: 2681306; HomoloGene: 47976; GeneCards: TAS2R38; OMA:TAS2R38 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	141,973,773 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	40,590,244 bp
RNA expression pattern
	Top expressed in
	rectum; ; mucosa of transverse colon; ; sural nerve; ; duodenum; ; placenta; ; mucosa of small intestine; ; smooth muscle tissue; ; male reproductive gland; ; prostate;
	Top expressed in
	proximal tubule;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; bitter taste receptor activity;
Cellular component	membrane; plasma membrane; integral component of membrane;
Biological process	detection of chemical stimulus involved in sensory perception of bitter taste; signal transduction; response to stimulus; sensory perception of taste; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5726
	387513
	ENSG00000257138
	ENSMUSG00000058250
	P59533
	Q7TQA6
	NM_176817
	NM_001001451
	NP_789787
	NP_001001451
	Wikidata
View/Edit Human	View/Edit Mouse

Taste receptor 2 member 38 is a protein that in humans is encoded by the TAS2R38 gene. TAS2R38 is a bitter taste receptor; varying genotypes of TAS2R38 influence the ability to taste both 6-n-propylthiouracil (PROP)^[5] and phenylthiocarbamide (PTC).^[6]^[7] Though it has often been proposed that varying taste receptor genotypes could influence tasting ability, TAS2R38 is one of the few taste receptors shown to have this function.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000257138 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058250 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Duffy VB, Davidson AC, Kidd JR, Kidd KK, Speed WC, Pakstis AJ, et al. (November 2004). "Bitter receptor gene (TAS2R38), 6-n-propylthiouracil (PROP) bitterness and alcohol intake". Alcoholism: Clinical and Experimental Research. 28 (11): 1629–1637. doi:10.1097/01.ALC.0000145789.55183.D4. PMC 1397913. PMID 15547448.
^ Prodi DA, Drayna D, Forabosco P, Palmas MA, Maestrale GB, Piras D, et al. (October 2004). "Bitter taste study in a sardinian genetic isolate supports the association of phenylthiocarbamide sensitivity to the TAS2R38 bitter receptor gene". Chemical Senses. 29 (8): 697–702. doi:10.1093/chemse/bjh074. PMID 15466815.
^ Kim UK, Drayna D (April 2005). "Genetics of individual differences in bitter taste perception: lessons from the PTC gene". Clinical Genetics. 67 (4): 275–280. doi:10.1111/j.1399-0004.2004.00361.x. PMID 15733260. S2CID 1639438.
^ Bachmanov AA, Beauchamp GK (2007). "Taste receptor genes". Annual Review of Nutrition. 27: 389–414. doi:10.1146/annurev.nutr.26.061505.111329. PMC 2721271. PMID 17444812.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000257138 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000058250 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[p155474482-5] Duffy VB, Davidson AC, Kidd JR, Kidd KK, Speed WC, Pakstis AJ, et al. (November 2004). "Bitter receptor gene (TAS2R38), 6-n-propylthiouracil (PROP) bitterness and alcohol intake". Alcoholism: Clinical and Experimental Research. 28 (11): 1629–1637. doi:10.1097/01.ALC.0000145789.55183.D4. PMC 1397913. PMID 15547448.

[p15466815-6] Prodi DA, Drayna D, Forabosco P, Palmas MA, Maestrale GB, Piras D, et al. (October 2004). "Bitter taste study in a sardinian genetic isolate supports the association of phenylthiocarbamide sensitivity to the TAS2R38 bitter receptor gene". Chemical Senses. 29 (8): 697–702. doi:10.1093/chemse/bjh074. PMID 15466815.

[p15733260-7] Kim UK, Drayna D (April 2005). "Genetics of individual differences in bitter taste perception: lessons from the PTC gene". Clinical Genetics. 67 (4): 275–280. doi:10.1111/j.1399-0004.2004.00361.x. PMID 15733260. S2CID 1639438.

[p17444812-8] Bachmanov AA, Beauchamp GK (2007). "Taste receptor genes". Annual Review of Nutrition. 27: 389–414. doi:10.1146/annurev.nutr.26.061505.111329. PMC 2721271. PMID 17444812.

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