T-box transcription factor 2 Tbx2 is a transcription factor that is encoded by the Tbx2 gene on chromosome 17q21-22 in humans.[5][6][7] This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. Tbx2 and Tbx3 are the only T-box transcription factors that act as transcriptional repressors rather than transcriptional activators, and are closely related in terms of development and tumorigenesis.[8] This gene plays a significant role in embryonic and fetal development through control of gene expression, and also has implications in various cancers. Tbx2 is associated with numerous signaling pathways, BMP, TGFβ, Wnt, and FGF, which allow for patterning and proliferation during organogenesis in fetal development.[8]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000121068 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000093 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Campbell C, Goodrich K, Casey G, Beatty B (July 1995). "Cloning and mapping of a human gene (TBX2) sharing a highly conserved protein motif with the Drosophila omb gene". Genomics. 28 (2): 255–260. doi:10.1006/geno.1995.1139. PMID 8530034.
- ^ EntrezGene 6909
- ^ Law DJ, Gebuhr T, Garvey N, Agulnik SI, Silver LM (November 1995). "Identification, characterization, and localization to chromosome 17q21-22 of the human TBX2 homolog, member of a conserved developmental gene family". Mammalian Genome. 6 (11): 793–797. doi:10.1007/bf00539006. hdl:2027.42/47017. PMID 8597636. S2CID 15779406.
- ^ a b Lu J, Li XP, Dong Q, Kung HF, He ML (December 2010). "TBX2 and TBX3: the special value for anticancer drug targets". Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1806 (2): 268–274. doi:10.1016/j.bbcan.2010.07.001. PMC 7127380. PMID 20624445.