TBX21

TBX21
Identifiers
Aliases	TBX21, T-PET, T-bet, TBET, TBLYM, T-box 21, T-box transcription factor 21, IMD88
External IDs	OMIM: 604895; MGI: 1888984; HomoloGene: 8353; GeneCards: TBX21; OMA:TBX21 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	47,746,122 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	97,006,157 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; testicle; ; spleen; ; lymph node; ; bone marrow cells; ; tibialis anterior muscle; ; mucosa of ileum; ; upper lobe of left lung; ; mononuclear cell;
	Top expressed in
	female urethra; ; blood; ; olfactory bulb; ; embryo; ; spleen; ; mesenteric lymph nodes; ; spinal ganglia; ; extraocular muscle; ; thymus; ; granulocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	soma; nucleus;
Biological process	multicellular organism development; positive regulation of transcription, DNA-templated; cellular response to organic substance; positive regulation of isotype switching to IgG isotypes; response to virus; T cell differentiation; regulation of transcription, DNA-templated; lymphocyte migration; transcription, DNA-templated; regulation of immune response; negative regulation of transcription by RNA polymerase II; negative regulation of interleukin-2 production; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of T cell differentiation; negative regulation of transcription, DNA-templated; negative regulation of T-helper 17 cell differentiation; negative regulation of T-helper 17 cell lineage commitment; negative regulation of T-helper 2 cell cytokine production; positive regulation of gene expression;
	Sources:Amigo / QuickGO
Orthologs
	30009
	57765
	ENSG00000073861
	ENSMUSG00000001444
	Q9UL17
	Q9JKD8
	NM_013351
	NM_019507
	NP_037483
	NP_062380
	Wikidata
View/Edit Human	View/Edit Mouse

T-box transcription factor TBX21, also called T-bet (T-box expressed in T cells), is a protein that in humans is encoded by the TBX21 gene.^[5] Though being for long thought of only as a master regulator of type 1 immune response, T-bet has recently been shown to be implicated in development of various immune cell subsets and maintenance of mucosal homeostasis.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000073861 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001444 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: TBX21 T-box 21".
^ Lazarevic V, Glimcher LH, Lord GM (November 2013). "T-bet: a bridge between innate and adaptive immunity". Nature Reviews. Immunology. 13 (11): 777–789. doi:10.1038/nri3536. PMC 6290922. PMID 24113868.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000073861 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001444 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: TBX21 T-box 21".

[Lazarevic_et_al_2013-6] Lazarevic V, Glimcher LH, Lord GM (November 2013). "T-bet: a bridge between innate and adaptive immunity". Nature Reviews. Immunology. 13 (11): 777–789. doi:10.1038/nri3536. PMC 6290922. PMID 24113868.

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