TCF4

TCF4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KWF
Identifiers
Aliases	TCF4, E2-2, ITF-2, ITF2, PTHS, SEF-2, SEF2, SEF2-1, SEF2-1A, SEF2-1B, SEF2-1D, TCF-4, bHLHb19, FECD3, transcription factor 4, CDG2T
External IDs	OMIM: 602272; MGI: 98506; HomoloGene: 2407; GeneCards: TCF4; OMA:TCF4 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q21.2 Start 55,222,185 bp[1] End 55,664,787 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 E2 Start 69,343,356 bp[2] End 69,689,079 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell skin of hip pericardium entorhinal cortex parietal lobe Achilles tendon postcentral gyrus Brodmann area 23 synovial joint ganglionic eminence Top expressed in Rostral migratory stream ganglionic eminence medial ganglionic eminence subiculum ventricular zone barrel cortex lobe of cerebellum dermis internal carotid artery hippocampus proper More reference expression data BioGPS n/a
Gene ontology Molecular function protein dimerization activity protein homodimerization activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific bHLH transcription factor binding E-box binding protein C-terminus binding protein binding identical protein binding TFIIB-class transcription factor binding protein heterodimerization activity DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component transcription regulator complex nucleus beta-catenin-TCF complex beta-catenin-TCF7L2 complex Biological process cell differentiation regulation of transcription, DNA-templated protein-DNA complex assembly transcription, DNA-templated nervous system development positive regulation of transcription, DNA-templated DNA-templated transcription, initiation transcription initiation from RNA polymerase II promoter positive regulation of transcription by RNA polymerase II positive regulation of neuron differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6925 21413 Ensembl ENSG00000196628 ENSMUSG00000053477 UniProt P15884 Q60722 RefSeq (mRNA) NM_001083962 NM_001243226 NM_001243227 NM_001243228 NM_001243230 NM_001243231 NM_001243232 NM_001243233 NM_001243234 NM_001243235 NM_001243236 NM_001306207 NM_001306208 NM_003199 NM_001330604 NM_001330605 NM_001348211 NM_001348212 NM_001348213 NM_001348214 NM_001348215 NM_001348216 NM_001348217 NM_001348218 NM_001348219 NM_001348220 NM_001369572 NM_001369573 NM_001369574 NM_001369575 NM_001369576 NM_001369577 NM_001369578 NM_001369579 NM_001369580 NM_001369581 NM_001369582 NM_001369583 NM_001369584 NM_001369585 NM_001369586 NM_001369567 NM_001369568 NM_001369569 NM_001369570 NM_001369571 NM_001083967 NM_013685 NM_001361126 NM_001361127 NM_001361128 NM_001361129 RefSeq (protein) NP_001077431 NP_001230155 NP_001230156 NP_001230157 NP_001230159 NP_001230160 NP_001230161 NP_001230162 NP_001230163 NP_001230164 NP_001230165 NP_001293136 NP_001293137 NP_001317533 NP_001317534 NP_003190 NP_001335140 NP_001335141 NP_001335142 NP_001335143 NP_001335144 NP_001335145 NP_001335146 NP_001335147 NP_001335148 NP_001335149 NP_001356501 NP_001356502 NP_001356503 NP_001356504 NP_001356505 NP_001356506 NP_001356507 NP_001356508 NP_001356509 NP_001356510 NP_001356511 NP_001356512 NP_001356513 NP_001356514 NP_001356515 NP_001356496 NP_001356497 NP_001356498 NP_001356499 NP_001356500 NP_001077436 NP_038713 NP_001348055 NP_001348056 NP_001348057 NP_001348058 Location (UCSC) Chr 18: 55.22 – 55.66 Mb Chr 18: 69.34 – 69.69 Mb PubMed search [3] [4]
Wikidata
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Transcription factor 4 (TCF-4) also known as immunoglobulin transcription factor 2 (ITF-2) is a protein that in humans is encoded by the TCF4 gene located on chromosome 18q21.2.^[5]