TCL1A

TCL1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JSG
Identifiers
Aliases	TCL1A, TCL1, T-cell leukemia/lymphoma 1A, T cell leukemia/lymphoma 1A, TCL1 family AKT coactivator A
External IDs	OMIM: 186960; MGI: 1097166; HomoloGene: 7565; GeneCards: TCL1A; OMA:TCL1A - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	95,714,196 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	105,189,052 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; gonad; ; granulocyte; ; lymph node; ; appendix; ; spleen; ; blood; ; testicle; ; bone marrow;
	Top expressed in
	zygote; ; secondary oocyte; ; primary oocyte; ; blastocyst; ; morula; ; embryo; ; ovary; ; CA3 field; ; gastrula; ; Gonadal ridge;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; protein kinase binding; identical protein binding; protein serine/threonine kinase activator activity;
Cellular component	cytoplasm; endoplasmic reticulum; intracellular membrane-bounded organelle; nucleus; protein-containing complex;
Biological process	multicellular organism development; positive regulation of cell population proliferation; positive regulation of mitochondrial membrane potential; positive regulation of protein oligomerization; positive regulation of peptidyl-serine phosphorylation; negative regulation of apoptotic process; protein homotrimerization; cellular response to tumor necrosis factor; positive regulation of protein serine/threonine kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	8115
	21432
	ENSG00000100721
	ENSMUSG00000041359
	P56279
	P56280
	NM_001098725; NM_021966
	NM_001289468; NM_009337; NM_001309484; NM_001309485
	NP_001092195; NP_068801; NP_001092195.1; NP_068801.1
	NP_001276397; NP_001296413; NP_001296414; NP_033363
	Wikidata
View/Edit Human	View/Edit Mouse

T-cell leukemia/lymphoma protein 1A is a protein that in humans is encoded by the TCL1A gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100721 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041359 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Russo G, Isobe M, Gatti R, Finan J, Batuman O, Huebner K, Nowell PC, Croce CM (February 1989). "Molecular analysis of a t(14;14) translocation in leukemic T-cells of an ataxia telangiectasia patient". Proc Natl Acad Sci U S A. 86 (2): 602–6. Bibcode:1989PNAS...86..602R. doi:10.1073/pnas.86.2.602. PMC 286520. PMID 2783489.
^ Virgilio L, Narducci MG, Isobe M, Billips LG, Cooper MD, Croce CM, Russo G (February 1995). "Identification of the TCL1 gene involved in T-cell malignancies". Proc Natl Acad Sci U S A. 91 (26): 12530–4. doi:10.1073/pnas.91.26.12530. PMC 45472. PMID 7809072.
^ "Entrez Gene: TCL1A T-cell leukemia/lymphoma 1A".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100721 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041359 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2783489-5] Russo G, Isobe M, Gatti R, Finan J, Batuman O, Huebner K, Nowell PC, Croce CM (February 1989). "Molecular analysis of a t(14;14) translocation in leukemic T-cells of an ataxia telangiectasia patient". Proc Natl Acad Sci U S A. 86 (2): 602–6. Bibcode:1989PNAS...86..602R. doi:10.1073/pnas.86.2.602. PMC 286520. PMID 2783489.

[pmid7809072-6] Virgilio L, Narducci MG, Isobe M, Billips LG, Cooper MD, Croce CM, Russo G (February 1995). "Identification of the TCL1 gene involved in T-cell malignancies". Proc Natl Acad Sci U S A. 91 (26): 12530–4. doi:10.1073/pnas.91.26.12530. PMC 45472. PMID 7809072.

[entrez-7] "Entrez Gene: TCL1A T-cell leukemia/lymphoma 1A".

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