TEAD2

TEAD2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3L15, 5DQE, 5DQ8, 5EMV, 5HGU
Identifiers
Aliases	TEAD2, ETF, TEAD-2, TEF-4, TEF4, TEA domain transcription factor 2
External IDs	OMIM: 601729; MGI: 104904; HomoloGene: 19662; GeneCards: TEAD2; OMA:TEAD2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	49,362,457 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	44,883,068 bp
RNA expression pattern
	Top expressed in
	vena cava; ; apex of heart; ; ganglionic eminence; ; tendon of biceps brachii; ; muscle layer of sigmoid colon; ; left ventricle; ; right auricle; ; smooth muscle tissue; ; ventricular zone; ; canal of the cervix;
	Top expressed in
	ventricular zone; ; epiblast; ; genital tubercle; ; tail of embryo; ; otic vesicle; ; mandibular prominence; ; medial ganglionic eminence; ; maxillary prominence; ; abdominal wall; ; hand;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; protein binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; sequence-specific DNA binding; transcription coactivator binding; protein heterodimerization activity; disordered domain specific binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleoplasm; cytosol; intracellular membrane-bounded organelle; nucleus; transcription regulator complex;
Biological process	transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-templated; hippo signaling; transcription, DNA-templated; vasculogenesis; embryonic heart tube morphogenesis; regulation of stem cell differentiation; notochord development; negative regulation of cell death; neural tube closure; paraxial mesoderm development; lateral mesoderm development; cellular response to retinoic acid; positive regulation of transcription by RNA polymerase II; embryonic organ development; positive regulation of transcription, DNA-templated; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	8463
	21677
	ENSG00000074219
	ENSMUSG00000030796
	Q15562
	P48301
NM_001256658; NM_001256659; NM_001256660; NM_001256661; NM_001256662;
	NM_003598
	NM_001285498; NM_001285500; NM_011565; NM_001379272; NM_001379273
NP_001243587; NP_001243588; NP_001243589; NP_001243590; NP_001243591;
	NP_003589
	NP_001272427; NP_001272429; NP_035695; NP_001366201; NP_001366202
	Wikidata
View/Edit Human	View/Edit Mouse

TEAD2 (ETF, ETEF-1, TEF-4), together with TEAD1, defines a novel family of transcription factors, the TEAD family, highly conserved through evolution.^[5]^[6] TEAD proteins were notably found in Drosophila (Scalloped), C. elegans (egl -44), S. cerevisiae and A. nidulans. TEAD2 has been less studied than TEAD1 but a few studies revealed its role during development.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000074219 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030796 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Xiao JH, Davidson I, Matthes H, Garnier JM, Chambon P (May 1991). "Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1". Cell. 65 (4): 551–68. doi:10.1016/0092-8674(91)90088-g. PMID 1851669. S2CID 34258565.
^ Mar JH, Ordahl CP (September 1988). "A conserved CATTCCT motif is required for skeletal muscle-specific activity of the cardiac troponin T gene promoter". Proceedings of the National Academy of Sciences of the United States of America. 85 (17): 6404–8. Bibcode:1988PNAS...85.6404M. doi:10.1073/pnas.85.17.6404. PMC 281980. PMID 3413104.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000074219 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030796 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Xiao JH, Davidson I, Matthes H, Garnier JM, Chambon P (May 1991). "Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1". Cell. 65 (4): 551–68. doi:10.1016/0092-8674(91)90088-g. PMID 1851669. S2CID 34258565.

[6] Mar JH, Ordahl CP (September 1988). "A conserved CATTCCT motif is required for skeletal muscle-specific activity of the cardiac troponin T gene promoter". Proceedings of the National Academy of Sciences of the United States of America. 85 (17): 6404–8. Bibcode:1988PNAS...85.6404M. doi:10.1073/pnas.85.17.6404. PMC 281980. PMID 3413104.

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