TEC (gene)

TEC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LUL
Identifiers
Aliases	TEC, PSCTK4, tec protein tyrosine kinase
External IDs	OMIM: 600583; MGI: 98662; HomoloGene: 1302; GeneCards: TEC; OMA:TEC - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	48,269,838 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	73,025,826 bp
RNA expression pattern
	Top expressed in
	gonad; ; bone marrow cells; ; testicle; ; skin of leg; ; skin of abdomen; ; monocyte; ; right uterine tube; ; rectum; ; right lung; ; right adrenal cortex;
	Top expressed in
	sciatic nerve; ; granulocyte; ; spleen; ; left lobe of liver; ; mesenteric lymph nodes; ; blood; ; proximal tubule; ; bone marrow; ; right kidney; ; iris;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; non-membrane spanning protein tyrosine kinase activity; metal ion binding; kinase activity; protein binding; protein tyrosine kinase activity; signaling receptor binding; phospholipid binding; ATP binding; lipid binding;
Cellular component	cytoplasm; cytosol; membrane; extrinsic component of cytoplasmic side of plasma membrane; cytoskeleton; plasma membrane;
Biological process	B cell receptor signaling pathway; cell differentiation; intracellular signal transduction; adaptive immune response; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; immune system process; Fc-epsilon receptor signaling pathway; protein phosphorylation; regulation of cell population proliferation; positive regulation of peptidyl-tyrosine phosphorylation; peptidyl-tyrosine autophosphorylation; integrin-mediated signaling pathway; peptidyl-tyrosine phosphorylation; regulation of platelet activation; innate immune response; tissue regeneration; cytokine-mediated signaling pathway; T cell receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7006
	21682
	ENSG00000135605
	ENSMUSG00000029217
	P42680
	P24604
	NM_003215
	NM_001113460; NM_001113461; NM_001113464; NM_013689
	NP_003206
	NP_001106931; NP_001106932; NP_001106935; NP_038717
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine-protein kinase Tec is a tyrosine kinase that in humans is encoded by the TEC gene.^[5]^[6] Tec kinase is expressed in hematopoietic, liver, and kidney cells and plays an important role in T-helper cell processes.^[7] Tec kinase is the name-giving member of the Tec kinase family, a family of non-receptor protein-tyrosine kinases.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135605 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029217 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sato K, Mano H, Ariyama T, Inazawa J, Yazaki Y, Hirai H (October 1994). "Molecular cloning and analysis of the human Tec protein-tyrosine kinase". Leukemia. 8 (10): 1663–72. PMID 7934162.
^ "Entrez Gene: TEC tec protein tyrosine kinase".
^ Schmidt U, Boucheron N, Unger B, Ellmeier W (May 2004). "The role of Tec family kinases in myeloid cells". International Archives of Allergy and Immunology. 134 (1): 65–78. doi:10.1159/000078339. PMID 15133303. S2CID 30963664.
^ Boucheron N, Ellmeier W (April 2012). "The role of Tec family kinases in the regulation of T-helper-cell differentiation". International Reviews of Immunology. 31 (2): 133–54. doi:10.3109/08830185.2012.664798. PMID 22449074. S2CID 1636844.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135605 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029217 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7934162-5] Sato K, Mano H, Ariyama T, Inazawa J, Yazaki Y, Hirai H (October 1994). "Molecular cloning and analysis of the human Tec protein-tyrosine kinase". Leukemia. 8 (10): 1663–72. PMID 7934162.

[entrez-6] "Entrez Gene: TEC tec protein tyrosine kinase".

[:0-7] Schmidt U, Boucheron N, Unger B, Ellmeier W (May 2004). "The role of Tec family kinases in myeloid cells". International Archives of Allergy and Immunology. 134 (1): 65–78. doi:10.1159/000078339. PMID 15133303. S2CID 30963664.

[:2-8] Boucheron N, Ellmeier W (April 2012). "The role of Tec family kinases in the regulation of T-helper-cell differentiation". International Reviews of Immunology. 31 (2): 133–54. doi:10.3109/08830185.2012.664798. PMID 22449074. S2CID 1636844.

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