Teneurin-3, also known as Ten-m3, Odz3, Ten-m/Odz3, Tenascin-like molecule major 3 or Teneurin transmembrane protein 3, is a protein that, in humans, is encoded by the TENM3, or ODZ3, gene.[5][6][7][8] Ten-m3 is a ~300 kDa type II transmembrane glycoprotein that is a member of the teneurin/Ten-m/Odz family. The teneurin family currently consists of four members: Ten-m1-Ten-m4. Ten-ms are conserved across both vertebrate and invertebrate species. They are expressed in distinct, but often interconnected, areas of the developing nervous system and in some non-neural tissues. Like the Ten-m family, Ten-m3 plays a critical role in regulating connectivity of the nervous system, particularly in axon pathfinding and synaptic organisation in the motor and visual system.[9][10] Mutation in the TENM3/ODZ3 gene in humans has been associated with the eye condition, microphthalmia.[11]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000218336 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031561 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Baumgartner S, Chiquet-Ehrismann R (March 1993). "Tena, a Drosophila gene related to tenascin, shows selective transcript localization". Mechanisms of Development. 40 (3): 165–76. doi:10.1016/0925-4773(93)90074-8. PMID 7684246. S2CID 38892756.
- ^ Levine A, Bashan-Ahrend A, Budai-Hadrian O, Gartenberg D, Menasherow S, Wides R (May 1994). "odd Oz: A novel Drosophila pair rule gene". Cell. 77 (4): 587–98. doi:10.1016/0092-8674(94)90220-8. PMID 7514504. S2CID 32035939.
- ^ Minet AD, Rubin BP, Tucker RP, Baumgartner S, Chiquet-Ehrismann R (June 1999). "Teneurin-1, a vertebrate homologue of the Drosophila pair-rule gene ten-m, is a neuronal protein with a novel type of heparin-binding domain". Journal of Cell Science. 112 (Pt 12): 2019–32. doi:10.1242/jcs.112.12.2019. PMID 10341219.
- ^ "Entrez Gene: TENM3 teneurin transmembrane protein 3". Retrieved 2017-10-22.
- ^ Tucker RP, Chiquet-Ehrismann R (February 2006). "Teneurins: A conserved family of transmembrane proteins involved in intercellular signaling during development". Developmental Biology. 290 (2): 237–45. doi:10.1016/j.ydbio.2005.11.038. PMID 16406038.
- ^ Young TR, Leamey CA (May 2009). "Teneurins: Important regulators of neural circuitry". International Journal of Biochemistry & Cell Biology. 41 (5): 990–3. doi:10.1016/j.biocel.2008.06.014. PMID 18723111.
- ^ Aldahmesh MA, Mohammed JY, Al-Hazzaa S, Alkuraya FS (November 2012). "Homozygous null mutation in ODZ3 causes microphthalmia in humans". Genetics in Medicine. 14 (11): 900–4. doi:10.1038/gim.2012.71. PMID 22766609.