TGM3

TGM3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1L9M, 1L9N, 1NUD, 1NUF, 1NUG
Identifiers
Aliases	TGM3, TGE, transglutaminase 3, UHS2
External IDs	OMIM: 600238; MGI: 98732; HomoloGene: 20690; GeneCards: TGM3; OMA:TGM3 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	2,341,079 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	129,892,319 bp
RNA expression pattern
	Top expressed in
	skin of leg; ; skin of abdomen; ; right uterine tube; ; tonsil; ; minor salivary glands; ; vagina; ; ectocervix; ; gallbladder; ; blood; ; granulocyte;
	Top expressed in
	esophagus; ; left colon; ; lip; ; superior surface of tongue; ; granulocyte; ; hair follicle; ; skin of back; ; skin of abdomen; ; trachea; ; pretectal area;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; calcium ion binding; catalytic activity; protein-glutamine gamma-glutamyltransferase activity; transferase activity; acyltransferase activity;
Cellular component	extrinsic component of cytoplasmic side of plasma membrane; extracellular exosome; cytoplasm;
Biological process	keratinization; protein tetramerization; hair follicle morphogenesis; cell envelope organization; peptide cross-linking; keratinocyte differentiation;
	Sources:Amigo / QuickGO
Orthologs
	7053
	21818
	ENSG00000125780
	ENSMUSG00000027401
	Q08188
	Q08189
	NM_003245
	NM_009374
	NP_003236
	NP_033400
	Wikidata
View/Edit Human	View/Edit Mouse

Protein-glutamine gamma-glutamyltransferase E is an enzyme that in humans is encoded by the TGM3 gene.^[5]^[6]^[7]

Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125780 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027401 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang M, Kim IG, Steinert PM, McBride OW (Mar 1995). "Assignment of the human transglutaminase 2 (TGM2) and transglutaminase 3 (TGM3) genes to chromosome 20q11.2". Genomics. 23 (3): 721–2. doi:10.1006/geno.1994.1571. PMID 7851911.
^ Aeschlimann D, Koeller MK, Allen-Hoffmann BL, Mosher DF (Mar 1998). "Isolation of a cDNA encoding a novel member of the transglutaminase gene family from human keratinocytes. Detection and identification of transglutaminase gene products based on reverse transcription-polymerase chain reaction with degenerate primers". J Biol Chem. 273 (6): 3452–60. doi:10.1074/jbc.273.6.3452. PMID 9452468.
^ ^a ^b "Entrez Gene: TGM3 transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125780 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027401 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7851911-5] Wang M, Kim IG, Steinert PM, McBride OW (Mar 1995). "Assignment of the human transglutaminase 2 (TGM2) and transglutaminase 3 (TGM3) genes to chromosome 20q11.2". Genomics. 23 (3): 721–2. doi:10.1006/geno.1994.1571. PMID 7851911.

[pmid9452468-6] Aeschlimann D, Koeller MK, Allen-Hoffmann BL, Mosher DF (Mar 1998). "Isolation of a cDNA encoding a novel member of the transglutaminase gene family from human keratinocytes. Detection and identification of transglutaminase gene products based on reverse transcription-polymerase chain reaction with degenerate primers". J Biol Chem. 273 (6): 3452–60. doi:10.1074/jbc.273.6.3452. PMID 9452468.

[entrez-7] "Entrez Gene: TGM3 transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)".

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