TLE1

TLE1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GXR, 2CE8, 2CE9, 4OM2, 4OM3
Identifiers
Aliases	TLE1, ESG, ESG1, GRG1, transducin like enhancer of split 1, TLE family member 1, transcriptional corepressor, TLE-1
External IDs	OMIM: 600189; MGI: 104636; HomoloGene: 21058; GeneCards: TLE1; OMA:TLE1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	81,689,547 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	72,119,156 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; sural nerve; ; endometrium; ; muscle of thigh; ; parotid gland; ; right lobe of liver; ; canal of the cervix; ; ganglionic eminence; ; gastrocnemius muscle; ; middle temporal gyrus;
	Top expressed in
	Rostral migratory stream; ; external carotid artery; ; seminal vesicula; ; internal carotid artery; ; mandibular prominence; ; ventricular zone; ; ganglionic eminence; ; superior cervical ganglion; ; maxillary prominence; ; vas deferens;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transcription corepressor activity; transcription factor binding; protein binding; identical protein binding;
Cellular component	cytosol; nucleus; nucleoplasm; beta-catenin-TCF complex; transcription regulator complex; cytoplasm; nucleolus;
Biological process	regulation of transcription, DNA-templated; negative regulation of Wnt signaling pathway; Wnt signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB signaling; transcription, DNA-templated; multicellular organism development; positive regulation of gene expression; animal organ morphogenesis; negative regulation of transcription, DNA-templated; negative regulation of anoikis; signal transduction; negative regulation of transcription by RNA polymerase II; beta-catenin-TCF complex assembly; negative regulation of canonical Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7088
	21885
	ENSG00000196781
	ENSMUSG00000008305
	Q04724
	Q62440
	NM_001303103; NM_001303104; NM_005077
	NM_001285529; NM_001285530; NM_001285531; NM_001285532; NM_011599
	NP_001290032; NP_001290033; NP_005068
	NP_001272458; NP_001272459; NP_001272460; NP_001272461; NP_035729
	Wikidata
View/Edit Human	View/Edit Mouse

Transducin-like enhancer protein 1 is a protein that in humans is encoded by the TLE1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196781 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000008305 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Miyasaka H, Choudhury BK, Hou EW, Li SS (Aug 1993). "Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein". European Journal of Biochemistry. 216 (1): 343–52. doi:10.1111/j.1432-1033.1993.tb18151.x. PMID 8365415.
^ Liu Y, Dehni G, Purcell KJ, Sokolow J, Carcangiu ML, Artavanis-Tsakonas S, Stifani S (Jan 1996). "Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia". Genomics. 31 (1): 58–64. doi:10.1006/geno.1996.0009. PMID 8808280.
^ "Entrez Gene: TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196781 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000008305 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8365415-5] Miyasaka H, Choudhury BK, Hou EW, Li SS (Aug 1993). "Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein". European Journal of Biochemistry. 216 (1): 343–52. doi:10.1111/j.1432-1033.1993.tb18151.x. PMID 8365415.

[pmid8808280-6] Liu Y, Dehni G, Purcell KJ, Sokolow J, Carcangiu ML, Artavanis-Tsakonas S, Stifani S (Jan 1996). "Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia". Genomics. 31 (1): 58–64. doi:10.1006/geno.1996.0009. PMID 8808280.

[entrez-7] "Entrez Gene: TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)".

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