TLQP-62

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Structures	Swiss-model
Domains	InterPro

VGF nerve growth factor inducible
VGF nerve growth factor inducible
Identifiers
Symbol	VGF
NCBI gene	7425
HGNC	12684
OMIM	602186
RefSeq	NM_003378
UniProt	O15240
Other data
Locus	Chr. 7 q22
Structures
Search for
Structures	Swiss-model
Domains	InterPro

TLQP-62 (amino acid 556-617) is a VGF-derived C-terminal peptide that was first discovered by Trani et al.^[1] TLQP-62 is derived from VGF precursor protein via proteolytic cleavage by prohormone convertases PC1/3 at the RPR⁵⁵⁵ site.^[2] TLQP-62 is named after its first four N-terminal amino acids and its peptide length.

^ Trani E, Ciotti T, Rinaldi AM, Canu N, Ferri GL, Levi A, Possenti R (December 1995). "Tissue-specific processing of the neuroendocrine protein VGF". Journal of Neurochemistry. 65 (6): 2441–9. doi:10.1046/j.1471-4159.1995.65062441.x. hdl:2108/56991. PMID 7595538. S2CID 22536787.
^ Trani E, Giorgi A, Canu N, Amadoro G, Rinaldi AM, Halban PA, Ferri GL, Possenti R, Schininà ME, Levi A (May 2002). "Isolation and characterization of VGF peptides in rat brain. Role of PC1/3 and PC2 in the maturation of VGF precursor". Journal of Neurochemistry. 81 (3): 565–74. doi:10.1046/j.1471-4159.2002.00842.x. hdl:2108/56929. PMID 12065665. S2CID 34357770.

[1] Trani E, Ciotti T, Rinaldi AM, Canu N, Ferri GL, Levi A, Possenti R (December 1995). "Tissue-specific processing of the neuroendocrine protein VGF". Journal of Neurochemistry. 65 (6): 2441–9. doi:10.1046/j.1471-4159.1995.65062441.x. hdl:2108/56991. PMID 7595538. S2CID 22536787.

[2] Trani E, Giorgi A, Canu N, Amadoro G, Rinaldi AM, Halban PA, Ferri GL, Possenti R, Schininà ME, Levi A (May 2002). "Isolation and characterization of VGF peptides in rat brain. Role of PC1/3 and PC2 in the maturation of VGF precursor". Journal of Neurochemistry. 81 (3): 565–74. doi:10.1046/j.1471-4159.2002.00842.x. hdl:2108/56929. PMID 12065665. S2CID 34357770.

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