TLX1

TLX1
Identifiers
Aliases	TLX1, HOX11, TCL3, T-cell leukemia homeobox 1, T cell leukemia homeobox 1
External IDs	OMIM: 186770; MGI: 98769; HomoloGene: 4031; GeneCards: TLX1; OMA:TLX1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	101,137,789 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	45,145,382 bp
RNA expression pattern
	Top expressed in
	spleen; ; testicle; ; minor salivary glands; ; gonad; ; right lobe of liver; ; mucosa of transverse colon; ; duodenum; ; tonsil; ; ventricle; ; left ventricle;
	Top expressed in
	dorsal mesentery; ; tongue; ; middle ear; ; submandibular gland; ; outer ear; ; auricle; ; skin of external ear; ; female urethra; ; male urethra; ; Eustachian tube;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor activity;
Cellular component	nucleus;
Biological process	multicellular organism development; regulation of transcription, DNA-templated; transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	3195
	21908
	ENSG00000107807
	ENSMUSG00000025215
	P31314
	P43345
	NM_001195517; NM_005521
	NM_021901
	NP_001182446; NP_005512
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

T-cell leukemia homeobox protein 1 is a protein that in humans is encoded by the TLX1 gene, which was initially named HOX11.^[5]^[6]^[7]^[8]^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000107807 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025215 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hatano M, Roberts CW, Minden M, Crist WM, Korsmeyer SJ (Jul 1991). "Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia". Science. 253 (5015): 79–82. Bibcode:1991Sci...253...79H. doi:10.1126/science.1676542. PMID 1676542.
^ McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
^ "Entrez Gene: TLX1 T-cell leukemia homeobox 1".
^ Kennedy MA, Gonzalez-Sarmiento R, Kees UR, Lampert F, Dear N, Boehm T, Rabbitts TH (Oct 1991). "HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24". Proceedings of the National Academy of Sciences of the United States of America. 88 (20): 8900–4. Bibcode:1991PNAS...88.8900K. doi:10.1073/pnas.88.20.8900. PMC 52618. PMID 1681546.
^ Dubé ID, Kamel-Reid S, Yuan CC, Lu M, Wu X, Corpus G, Raimondi SC, Crist WM, Carroll AJ, Minowada J (Dec 1991). "A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14)". Blood. 78 (11): 2996–3003. doi:10.1182/blood.V78.11.2996.2996. PMID 1683261.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000107807 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025215 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1676542-5] Hatano M, Roberts CW, Minden M, Crist WM, Korsmeyer SJ (Jul 1991). "Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia". Science. 253 (5015): 79–82. Bibcode:1991Sci...253...79H. doi:10.1126/science.1676542. PMID 1676542.

[pmid1973146-6] McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.

[entrez-7] "Entrez Gene: TLX1 T-cell leukemia homeobox 1".

[8] Kennedy MA, Gonzalez-Sarmiento R, Kees UR, Lampert F, Dear N, Boehm T, Rabbitts TH (Oct 1991). "HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24". Proceedings of the National Academy of Sciences of the United States of America. 88 (20): 8900–4. Bibcode:1991PNAS...88.8900K. doi:10.1073/pnas.88.20.8900. PMC 52618. PMID 1681546.

[9] Dubé ID, Kamel-Reid S, Yuan CC, Lu M, Wu X, Corpus G, Raimondi SC, Crist WM, Carroll AJ, Minowada J (Dec 1991). "A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14)". Blood. 78 (11): 2996–3003. doi:10.1182/blood.V78.11.2996.2996. PMID 1683261.

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