TMIGD1

TMIGD1
Identifiers
Aliases	TMIGD1, TMIGD, UNQ9372, transmembrane and immunoglobulin domain containing 1
External IDs	MGI: 1913851; HomoloGene: 41641; GeneCards: TMIGD1; OMA:TMIGD1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	30,334,059 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	76,807,413 bp
RNA expression pattern
	Top expressed in
	rectum; ; mucosa of transverse colon; ; epithelium of colon; ; human kidney; ; smooth muscle tissue; ; duodenum; ; appendix; ; renal cortex; ; muscle layer of sigmoid colon; ; lymph node;
	Top expressed in
	intestinal villus; ; right kidney; ; human kidney; ; ileum; ; Paneth cell; ; proximal tubule; ; jejunum; ; esophagus; ; submandibular gland; ; epithelium of small intestine;
	More reference expression data
	n/a
Orthologs
	388364
	66601
	ENSG00000182271
	ENSMUSG00000020839
	Q6UXZ0
	Q9D7L8
	NM_206832; NM_001319942
	NM_025655; NM_001382246; NM_001382247
	NP_001306871; NP_996663
	NP_079931; NP_001369175; NP_001369176
	Wikidata
View/Edit Human	View/Edit Mouse

Transmembrane and immunoglobulin domain containing 1 is a protein that in humans is encoded by the TMIGD1 gene.^[5] TMIGD1 was discovered by the lab of Giancarlo Marra^[6] and later cloned by Nader Rahimi.^[7]^[8] Recent findings suggest functions in brush border formation (intestinal epithelium) and roles as tumor suppressor (kidney and intestine).^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182271 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020839 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Transmembrane and immunoglobulin domain containing 1". Retrieved 2017-02-20.
^ Cattaneo E, Laczko E, Buffoli F, Zorzi F, Bianco MA, Menigatti M, et al. (May 2011). "Preinvasive colorectal lesion transcriptomes correlate with endoscopic morphology (polypoid vs. nonpolypoid)". EMBO Mol Med. 3 (6): 334–347. doi:10.1002/emmm.201100141. PMC 5839393. PMID 3377079.
^ Meyer RD, Zou X, Ali M, Ersoy E, Bondzie PA, Lavaei M, et al. (February 2018). "TMIGD1 acts as a tumor suppressor through regulation of p21Cip1/p27Kip1 in renal cancer". Oncotarget. 9 (11): 9672–9684. doi:10.18632/oncotarget.23822. PMC 5839393. PMID 29515762.
^ Arafa E, Bondzie PA, Rezazadeh K, Meyer RD, Hartsough E, Henderson JM, et al. (October 2015). "TMIGD1 is a novel adhesion molecule that protects epithelial cells from oxidative cell injury". The American Journal of Pathology. 185 (10): 2757–67. doi:10.1016/j.ajpath.2015.06.006. PMC 4607757. PMID 26342724.
^ Thuering E, et al. (April 2023). "TMIGD1: Emerging functions of a tumor suppressor and adhesion receptor". Oncogene. 42 (22): 1777–1785. doi:10.1038/s41388-023-02696-5. PMC 10238269. PMID 37087524.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000182271 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020839 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Transmembrane and immunoglobulin domain containing 1". Retrieved 2017-02-20.

[6] Cattaneo E, Laczko E, Buffoli F, Zorzi F, Bianco MA, Menigatti M, et al. (May 2011). "Preinvasive colorectal lesion transcriptomes correlate with endoscopic morphology (polypoid vs. nonpolypoid)". EMBO Mol Med. 3 (6): 334–347. doi:10.1002/emmm.201100141. PMC 5839393. PMID 3377079.

[7] Meyer RD, Zou X, Ali M, Ersoy E, Bondzie PA, Lavaei M, et al. (February 2018). "TMIGD1 acts as a tumor suppressor through regulation of p21Cip1/p27Kip1 in renal cancer". Oncotarget. 9 (11): 9672–9684. doi:10.18632/oncotarget.23822. PMC 5839393. PMID 29515762.

[8] Arafa E, Bondzie PA, Rezazadeh K, Meyer RD, Hartsough E, Henderson JM, et al. (October 2015). "TMIGD1 is a novel adhesion molecule that protects epithelial cells from oxidative cell injury". The American Journal of Pathology. 185 (10): 2757–67. doi:10.1016/j.ajpath.2015.06.006. PMC 4607757. PMID 26342724.

[9] Thuering E, et al. (April 2023). "TMIGD1: Emerging functions of a tumor suppressor and adhesion receptor". Oncogene. 42 (22): 1777–1785. doi:10.1038/s41388-023-02696-5. PMC 10238269. PMID 37087524.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]