TMPRSS2

TMPRSS2
Identifiers
Aliases	TMPRSS2, PP9284, PRSS10, transmembrane protease, serine 2, transmembrane serine protease 2
External IDs	OMIM: 602060; MGI: 1354381; HomoloGene: 4136; GeneCards: TMPRSS2; OMA:TMPRSS2 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	41,531,116 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	97,412,395 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; mucosa of sigmoid colon; ; body of pancreas; ; rectum; ; prostate; ; parotid gland; ; duodenum; ; mucosa of ileum; ; olfactory zone of nasal mucosa; ; pylorus;
	Top expressed in
	Paneth cell; ; transitional epithelium of urinary bladder; ; left colon; ; crypt of lieberkuhn of small intestine; ; epithelium of stomach; ; yolk sac; ; mucous cell of stomach; ; medullary collecting duct; ; pyloric antrum; ; duodenum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	scavenger receptor activity; peptidase activity; serine-type peptidase activity; protein binding; hydrolase activity; serine-type endopeptidase activity;
Cellular component	integral component of membrane; extracellular region; plasma membrane; integral component of plasma membrane; extracellular exosome; membrane;
Biological process	positive regulation of viral entry into host cell; protein autoprocessing; receptor-mediated endocytosis; proteolysis; vesicle-mediated transport; endocytosis;
	Sources:Amigo / QuickGO
Orthologs
	7113
	50528
	ENSG00000184012
	ENSMUSG00000000385
	O15393
	Q9JIQ8
	NM_001135099; NM_005656; NM_001382720
	NM_015775
	NP_001128571; NP_005647; NP_001369649
	NP_056590
	Wikidata
View/Edit Human	View/Edit Mouse

Transmembrane protease, serine 2 is an enzyme that in humans is encoded by the TMPRSS2 gene.^[5]^[6]^[7] It belongs to the TMPRSS family of proteins, whose members are transmembrane proteins which have a serine protease activity.^[8] The TMPRSS2 protein is found in high concentration in the cell membranes of epithelial cells of the lung and of the prostate, but also in the heart, liver and gastrointestinal tract.^[8]

Mutations of the TMPRSS2 gene are often involved in prostate cancer. Several viruses, including SARS-CoV-2, use the protease activity of the TMPRSS2 protein in the process of entering cells.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000184012 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000385 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Paoloni-Giacobino A, Chen H, Peitsch MC, Rossier C, Antonarakis SE (September 1997). "Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3". Genomics. 44 (3): 309–320. doi:10.1006/geno.1997.4845. PMID 9325052.
^ "Entrez Gene: TMPRSS2 transmembrane protease, serine 2".
^ "UniProt Protein: TMPS2_HUMAN transmembrane protease".
^ ^a ^b ^c Thunders M, Delahunt B (December 2020). "Gene of the month: TMPRSS2 (transmembrane serine protease 2)". Journal of Clinical Pathology. 73 (12): 773–776. doi:10.1136/jclinpath-2020-206987. PMC 7470178. PMID 32873700.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000184012 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000385 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9325052-5] Paoloni-Giacobino A, Chen H, Peitsch MC, Rossier C, Antonarakis SE (September 1997). "Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3". Genomics. 44 (3): 309–320. doi:10.1006/geno.1997.4845. PMID 9325052.

[entrez-6] "Entrez Gene: TMPRSS2 transmembrane protease, serine 2".

[uniprot-7] "UniProt Protein: TMPS2_HUMAN transmembrane protease".

[Thunders-2020-8] Thunders M, Delahunt B (December 2020). "Gene of the month: TMPRSS2 (transmembrane serine protease 2)". Journal of Clinical Pathology. 73 (12): 773–776. doi:10.1136/jclinpath-2020-206987. PMC 7470178. PMID 32873700.

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