TNNI2

TNNI2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MKP
Identifiers
Aliases	TNNI2, AMCD2B, DA2B, FSSV, fsTnI, troponin I2, fast skeletal type, DA2B1
External IDs	OMIM: 191043; MGI: 105070; HomoloGene: 37752; GeneCards: TNNI2; OMA:TNNI2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	1,841,680 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	141,998,147 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; skeletal muscle tissue; ; gastrocnemius muscle; ; skin of leg; ; skin of abdomen; ; blood; ; minor salivary glands; ; granulocyte; ; monocyte; ; olfactory zone of nasal mucosa;
	Top expressed in
	digastric muscle; ; sternocleidomastoid muscle; ; triceps brachii muscle; ; temporal muscle; ; medial head of gastrocnemius muscle; ; intercostal muscle; ; ankle; ; muscle of thigh; ; body of femur; ; esophagus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin binding; troponin T binding; protein binding;
Cellular component	cytosol; troponin complex; nucleus;
Biological process	regulation of muscle contraction; positive regulation of transcription, DNA-templated; skeletal muscle contraction; cardiac muscle contraction; muscle filament sliding; muscle contraction;
	Sources:Amigo / QuickGO
Orthologs
	7136
	21953
	ENSG00000130598; ENSG00000288219
	ENSMUSG00000031097
	P48788
	P13412
	NM_003282; NM_001145829; NM_001145841
	NM_009405
	NP_001139301; NP_001139313; NP_003273
	NP_033431
	Wikidata
View/Edit Human	View/Edit Mouse

Troponin I, fast skeletal muscle is a protein that in humans is encoded by the TNNI2 gene.^[5]^[6]

The TNNI2 gene is located at 11p15.5 in the human chromosomal genome, encoding the fast twitch skeletal muscle troponin I (fsTnI). fsTnI is a 21.3 kDa protein consisting of 182 amino acids including the first methionine with an isoelectric point (pI) of 8.74. It is the inhibitory subunit of the troponin complex in fast twitch skeletal muscle fibers.^[7]

^ ^a ^b ^c ENSG00000288219 GRCh38: Ensembl release 89: ENSG00000130598, ENSG00000288219 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031097 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tiso N, Rampoldi L, Pallavicini A, Zimbello R, Pandolfo D, Valle G, Lanfranchi G, Danieli GA (Jan 1997). "Fine mapping of five human skeletal muscle genes: alpha-tropomyosin, beta-tropomyosin, troponin-I slow-twitch, troponin-I fast-twitch, and troponin-C fast". Biochemical and Biophysical Research Communications. 230 (2): 347–50. doi:10.1006/bbrc.1996.5958. hdl:11577/2466889. PMID 9016781.
^ "Entrez Gene: TNNI2 troponin I type 2 (skeletal, fast)".
^ Jin JP, Zhang Z, Bautista JA (2008-01-01). "Isoform diversity, regulation, and functional adaptation of troponin and calponin". Critical Reviews in Eukaryotic Gene Expression. 18 (2): 93–124. doi:10.1615/critreveukargeneexpr.v18.i2.10. PMID 18304026.

[refGRCh38Ensembl-1] ENSG00000288219 GRCh38: Ensembl release 89: ENSG00000130598, ENSG00000288219 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031097 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9016781-5] Tiso N, Rampoldi L, Pallavicini A, Zimbello R, Pandolfo D, Valle G, Lanfranchi G, Danieli GA (Jan 1997). "Fine mapping of five human skeletal muscle genes: alpha-tropomyosin, beta-tropomyosin, troponin-I slow-twitch, troponin-I fast-twitch, and troponin-C fast". Biochemical and Biophysical Research Communications. 230 (2): 347–50. doi:10.1006/bbrc.1996.5958. hdl:11577/2466889. PMID 9016781.

[entrez-6] "Entrez Gene: TNNI2 troponin I type 2 (skeletal, fast)".

[7] Jin JP, Zhang Z, Bautista JA (2008-01-01). "Isoform diversity, regulation, and functional adaptation of troponin and calponin". Critical Reviews in Eukaryotic Gene Expression. 18 (2): 93–124. doi:10.1615/critreveukargeneexpr.v18.i2.10. PMID 18304026.

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