TOP1

TOP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A31, 1A35, 1A36, 1EJ9, 1K4S, 1K4T, 1LPQ, 1NH3, 1R49, 1RR8, 1RRJ, 1SC7, 1SEU, 1T8I, 1TL8
Identifiers
Aliases	TOP1, TOPI, topoisomerase (DNA) I, DNA topoisomerase I
External IDs	OMIM: 126420; MGI: 98788; HomoloGene: 2467; GeneCards: TOP1; OMA:TOP1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q12 Start 41,028,822 bp[1] End 41,124,487 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H2|2 80.96 cM Start 160,487,808 bp[2] End 160,564,684 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte ventricular zone ganglionic eminence secondary oocyte pericardium pylorus vena cava pancreatic ductal cell superior surface of tongue monocyte Top expressed in Ileal epithelium zygote secondary oocyte maxillary prominence mandibular prominence tail of embryo human fetus genital tubercle ventricular zone ganglionic eminence More reference expression data BioGPS n/a
Gene ontology Molecular function DNA topoisomerase type I (single strand cut, ATP-independent) activity chromatin binding isomerase activity DNA topoisomerase activity core promoter sequence-specific DNA binding protein binding RNA binding DNA binding double-stranded DNA binding single-stranded DNA binding protein serine/threonine kinase activity ATP binding protein domain specific binding supercoiled DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component cytoplasm perikaryon P-body replication fork protection complex chromosome nuclear chromosome nucleus fibrillar center nucleoplasm nucleolus DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex protein-DNA complex Biological process chromatin remodeling embryonic cleavage programmed cell death phosphorylation rhythmic process chromosome segregation protein sumoylation circadian regulation of gene expression DNA replication circadian rhythm viral process DNA topological change peptidyl-serine phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7150 21969 Ensembl ENSG00000198900 ENSMUSG00000070544 UniProt P11387 Q04750 RefSeq (mRNA) NM_003286 NM_009408 RefSeq (protein) NP_003277 NP_033434 Location (UCSC) Chr 20: 41.03 – 41.12 Mb Chr 2: 160.49 – 160.56 Mb PubMed search [3] [4]
Wikidata
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DNA topoisomerase 1 is an enzyme that in humans is encoded by the TOP1 gene. It is a DNA topoisomerase, an enzyme that catalyzes the transient breaking and rejoining of a single strand of DNA.