TP63

TP63
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4A9Z, 1RG6, 2RMN, 2Y9T, 2Y9U, 3QYM, 3QYN, 3US0, 3US1, 3US2, 3ZY0, 3ZY1
Identifiers
Aliases	TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L, tumor protein p63
External IDs	OMIM: 603273; MGI: 1330810; HomoloGene: 31189; GeneCards: TP63; OMA:TP63 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q28 Start 189,631,389 bp[1] End 189,897,276 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 B1|16 17.37 cM Start 25,502,513 bp[2] End 25,710,852 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh skin of hip skin of arm human penis hair follicle vulva gums nipple skin of abdomen gingival epithelium Top expressed in hair follicle molar skin of external ear conjunctival fornix skin of back transitional epithelium of urinary bladder corneal stroma lip superior surface of tongue genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription activator activity, RNA polymerase II-specific metal ion binding damaged DNA binding protein binding WW domain binding double-stranded DNA binding DNA binding sequence-specific DNA binding identical protein binding chromatin binding p53 binding DNA-binding transcription factor activity MDM2/MDM4 family protein binding DNA-binding transcription factor activity, RNA polymerase II-specific protein domain specific binding Cellular component cytoplasm neuron projection nucleus rough endoplasmic reticulum transcription regulator complex nucleoplasm dendrite mitochondrion Golgi apparatus cytosol protein-containing complex Biological process pattern specification process skeletal system development epithelial cell development negative regulation of keratinocyte differentiation epidermal cell division anatomical structure formation involved in morphogenesis prostate gland development transcription by RNA polymerase II squamous basal epithelial stem cell differentiation involved in prostate gland acinus development ectoderm and mesoderm interaction cellular response to DNA damage stimulus female genitalia morphogenesis odontogenesis of dentin-containing tooth prostatic bud formation positive regulation of cell cycle G1/S phase transition positive regulation of mesenchymal cell proliferation spermatogenesis multicellular organism aging smooth muscle tissue development positive regulation of fibroblast apoptotic process animal organ morphogenesis hair follicle morphogenesis positive regulation of Notch signaling pathway apoptotic process chromatin remodeling regulation of transcription, DNA-templated regulation of neuron apoptotic process positive regulation of apoptotic signaling pathway regulation of cysteine-type endopeptidase activity involved in apoptotic process transcription, DNA-templated embryonic limb morphogenesis negative regulation of mesoderm development epidermis development post-anal tail morphogenesis response to gamma radiation protein homotetramerization Notch signaling pathway hair follicle development neuron apoptotic process polarized epithelial cell differentiation proximal/distal pattern formation cell differentiation positive regulation of keratinocyte proliferation skin morphogenesis epithelial cell differentiation urinary bladder development cellular response to UV establishment of planar polarity negative regulation of apoptotic process negative regulation of transcription by RNA polymerase II protein tetramerization keratinocyte proliferation positive regulation of osteoblast differentiation regulation of epidermal cell division negative regulation of transcription, DNA-templated negative regulation of cellular senescence intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator sympathetic nervous system development establishment of skin barrier morphogenesis of a polarized epithelium keratinocyte differentiation multicellular organism development mitotic G1 DNA damage checkpoint signaling cloacal septation response to X-ray positive regulation of transcription by RNA polymerase II DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway regulation of signal transduction by p53 class mediator regulation of apoptotic process human ageing negative regulation of intracellular estrogen receptor signaling pathway positive regulation of transcription, DNA-templated positive regulation of somatic stem cell population maintenance cell population proliferation epidermal cell differentiation embryonic forelimb morphogenesis embryonic hindlimb morphogenesis skin epidermis development cranial skeletal system development developmental process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8626 22061 Ensembl ENSG00000073282 ENSMUSG00000022510 UniProt Q9H3D4 O88898 RefSeq (mRNA) NM_001114978 NM_001114979 NM_001114980 NM_001114981 NM_001114982 NM_003722 NM_001329144 NM_001329145 NM_001329146 NM_001329148 NM_001329149 NM_001329150 NM_001329964 NM_001127259 NM_001127260 NM_001127261 NM_001127262 NM_001127263 NM_001127264 NM_001127265 NM_011641 RefSeq (protein) NP_001108450 NP_001108451 NP_001108452 NP_001108453 NP_001108454 NP_001316073 NP_001316074 NP_001316075 NP_001316077 NP_001316078 NP_001316079 NP_001316893 NP_003713 NP_001120731 NP_001120732 NP_001120733 NP_001120734 NP_001120735 NP_001120736 NP_001120737 NP_035771 Location (UCSC) Chr 3: 189.63 – 189.9 Mb Chr 16: 25.5 – 25.71 Mb PubMed search [3] [4]
Wikidata
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Tumor protein p63, typically referred to as p63, also known as transformation-related protein 63, is a protein that in humans is encoded by the TP63 (also known as the p63) gene.^[5][6][7][8]

The TP63 gene was discovered 20 years after the discovery of the p53 tumor suppressor gene and along with p73 constitutes the p53 gene family based on their structural similarity.^[9] Despite being discovered significantly later than p53, phylogenetic analysis of p53, p63 and p73, suggest that p63 was the original member of the family from which p53 and p73 evolved.^[10]