TPBG

TPBG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4CNC, 4CNM
Identifiers
Aliases	TPBG, 5T4, 5T4AG, M6P1, WAIF1, trophoblast glycoprotein
External IDs	OMIM: 190920; MGI: 1341264; HomoloGene: 4859; GeneCards: TPBG; OMA:TPBG - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	82,367,420 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	85,729,093 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; gastric mucosa; ; urinary bladder; ; mucosa of esophagus; ; Descending thoracic aorta; ; canal of the cervix; ; ascending aorta; ; gonad; ; vagina; ; minor salivary glands;
	Top expressed in
	inferior colliculi; ; aortic valve; ; lumbar subsegment of spinal cord; ; medullary collecting duct; ; urothelium; ; transitional epithelium of urinary bladder; ; molar; ; cumulus cell; ; skin of external ear; ; decidua;
	More reference expression data
	More reference expression data
Orthologs
	7162
	21983
	ENSG00000146242; ENSG00000283085
	ENSMUSG00000035274
	Q13641
	Q9Z0L0
	NM_001166392; NM_006670; NM_001376922
	NM_001164792; NM_011627
	NP_001159864; NP_006661; NP_001363851
	NP_001158264; NP_035757
	Wikidata
View/Edit Human	View/Edit Mouse

Trophoblast glycoprotein, also known as TPBG, 5T4, Wnt-Activated Inhibitory Factor 1 or WAIF1, is a human protein encoded by a TPBG gene.^[5] TPBG is an antagonist of Wnt/β-catenin signalling pathway.^[6]

^ ^a ^b ^c ENSG00000283085 GRCh38: Ensembl release 89: ENSG00000146242, ENSG00000283085 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035274 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: TPBG trophoblast glycoprotein".
^ Zhao Y, Malinauskas T, Harlos K, Jones EY (Apr 2014). "Structural insights into the inhibition of Wnt signaling by cancer antigen 5T4/Wnt-activated inhibitory factor 1". Structure. 22 (4): 612–20. doi:10.1016/j.str.2014.01.009. PMC 3988984. PMID 24582434.

[refGRCh38Ensembl-1] ENSG00000283085 GRCh38: Ensembl release 89: ENSG00000146242, ENSG00000283085 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035274 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: TPBG trophoblast glycoprotein".

[pmid24582434-6] Zhao Y, Malinauskas T, Harlos K, Jones EY (Apr 2014). "Structural insights into the inhibition of Wnt signaling by cancer antigen 5T4/Wnt-activated inhibitory factor 1". Structure. 22 (4): 612–20. doi:10.1016/j.str.2014.01.009. PMC 3988984. PMID 24582434.

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