TPCN2

TPCN2
Identifiers
Aliases	TPCN2, SHEP10, TPC2, two pore segment channel 2
External IDs	OMIM: 612163; MGI: 2385297; HomoloGene: 16375; GeneCards: TPCN2; OMA:TPCN2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	69,136,316 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	144,837,748 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; mucosa of ileum; ; gastric mucosa; ; muscle layer of sigmoid colon; ; body of uterus; ; monocyte; ; right hemisphere of cerebellum; ; tibialis anterior muscle; ; left uterine tube; ; right lobe of liver;
	Top expressed in
	granulocyte; ; inner renal medulla; ; stroma of bone marrow; ; lip; ; ventricular zone; ; spermatid; ; yolk sac; ; embryo; ; blastocyst; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium channel activity; voltage-gated ion channel activity; ion channel activity; protein binding; identical protein binding; protein kinase binding; NAADP-sensitive calcium-release channel activity; voltage-gated calcium channel activity;
Cellular component	integral component of membrane; membrane; plasma membrane; endosome membrane; lysosome; lysosomal membrane;
Biological process	release of sequestered calcium ion into cytosol; membrane depolarization during action potential; response to vitamin D; regulation of ion transmembrane transport; cellular calcium ion homeostasis; ion transport; ion transmembrane transport; regulation of autophagy; calcium ion transmembrane transport; lysosome organization; calcium-mediated signaling; calcium ion transport; transmembrane transport; smooth muscle contraction;
	Sources:Amigo / QuickGO
Orthologs
	219931
	233979
	ENSG00000162341
	ENSMUSG00000048677
	Q8NHX9
	Q8BWC0
	NM_139075
	NM_146206
	NP_620714
	NP_666318
	Wikidata
View/Edit Human	View/Edit Mouse

Two pore segment channel 2 (TPC2) is a protein which in humans is encoded by the TPCN2 gene.^[5] TPC2 is an ion channel, however, in contrast to other calcium and sodium channels which have four homologous domains, each containing 6 transmembrane segments (S1 to S6), TPCN1 only contains two domain (each containing segments S1 to S6).^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162341 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048677 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: two pore segment channel 2".
^ Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacological Reviews. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101. S2CID 35096827.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162341 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048677 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: two pore segment channel 2".

[pmid16382101-6] Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacological Reviews. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101. S2CID 35096827.

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