TPH1

TPH1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MLW, 3HF6, 3HF8, 3HFB, 5J6D
Identifiers
Aliases	TPH1, TPRH, TRPH, tryptophan hydroxylase 1
External IDs	OMIM: 191060; MGI: 98796; HomoloGene: 121565; GeneCards: TPH1; OMA:TPH1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	18,046,269 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	46,321,961 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; rectum; ; ascending aorta; ; Descending thoracic aorta; ; mucosa of sigmoid colon; ; testicle; ; pylorus; ; tibial arteries; ; jejunal mucosa; ; duodenum;
	Top expressed in
	pineal gland; ; duodenum; ; lactiferous gland; ; pyloric antrum; ; embryo; ; embryo; ; jejunum; ; muscle of thigh; ; left colon; ; extraocular muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	iron ion binding; metal ion binding; monooxygenase activity; tryptophan 5-monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen; oxidoreductase activity;
Cellular component	cytoplasm; cytosol; neuron projection;
Biological process	response to immobilization stress; mammary gland alveolus development; serotonin biosynthetic process; negative regulation of ossification; aromatic amino acid family metabolic process; bone remodeling; circadian rhythm; positive regulation of fat cell differentiation; indolalkylamine biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	7166
	21990
	ENSG00000129167
	ENSMUSG00000040046
	P17752
	P17532
	NM_004179
	NM_001136084; NM_001276372; NM_009414
	NP_004170
	NP_001129556; NP_001263301; NP_033440
	Wikidata
View/Edit Human	View/Edit Mouse

Tryptophan hydroxylase 1 (TPH1) is an isoenzyme of tryptophan hydroxylase which in humans is encoded by the TPH1 gene.^[5]

TPH1 was first discovered to support serotonin synthesis in 1988 by converting tryptophan into 5-hydroxytryptophan.^[6] It was thought that there only was a single TPH gene until 2003. A second form was found in the mouse (Tph2), rat and human brain (TPH2) and the original TPH was then renamed to TPH1.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000129167 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040046 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: TPH1 tryptophan hydroxylase 1 (tryptophan 5-monooxygenase)".
^ Finocchiaro LM, Arzt ES, Fernández-Castelo S, Criscuolo M, Finkielman S, Nahmod VE (December 1988). "Serotonin and melatonin synthesis in peripheral blood mononuclear cells: stimulation by interferon-gamma as part of an immunomodulatory pathway". J. Interferon Res. 8 (6): 705–16. doi:10.1089/jir.1988.8.705. PMID 3148005.
^ Walther DJ, Peter JU, Bashammakh S, Hörtnagl H, Voits M, Fink H, Bader M (January 2003). "Synthesis of serotonin by a second tryptophan hydroxylase isoform". Science. 299 (5603): 76. doi:10.1126/science.1078197. PMID 12511643. S2CID 7095712.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000129167 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040046 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: TPH1 tryptophan hydroxylase 1 (tryptophan 5-monooxygenase)".

[pmid3148005-6] Finocchiaro LM, Arzt ES, Fernández-Castelo S, Criscuolo M, Finkielman S, Nahmod VE (December 1988). "Serotonin and melatonin synthesis in peripheral blood mononuclear cells: stimulation by interferon-gamma as part of an immunomodulatory pathway". J. Interferon Res. 8 (6): 705–16. doi:10.1089/jir.1988.8.705. PMID 3148005.

[Walther_2003-7] Walther DJ, Peter JU, Bashammakh S, Hörtnagl H, Voits M, Fink H, Bader M (January 2003). "Synthesis of serotonin by a second tryptophan hydroxylase isoform". Science. 299 (5603): 76. doi:10.1126/science.1078197. PMID 12511643. S2CID 7095712.

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