TPH2

TPH2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTPH2, ADHD7, NTPH, tryptophan hydroxylase 2
External IDsOMIM: 607478; MGI: 2651811; HomoloGene: 27831; GeneCards: TPH2; OMA:TPH2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_173353

NM_173391

RefSeq (protein)

NP_775489

NP_775567

Location (UCSC)Chr 12: 71.94 – 72.19 MbChr 10: 114.91 – 115.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tryptophan hydroxylase 2 (TPH2) is an isozyme of tryptophan hydroxylase found in vertebrates. In humans, TPH2 is primarily expressed in the serotonergic neurons of the brain, with the highest expression in the raphe nucleus of the midbrain. Until the discovery of TPH2 in 2003,[5] serotonin levels in the central nervous system were believed to be regulated by serotonin synthesis in peripheral tissues, in which tryptophan hydroxylase is the dominant form.[6]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000139287Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006764Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Walther DJ, Peter JU, Bashammakh S, Hörtnagl H, Voits M, Fink H, Bader M (January 2003). "Synthesis of serotonin by a second tryptophan hydroxylase isoform". Science. 299 (5603): 76. doi:10.1126/science.1078197. PMID 12511643. S2CID 7095712.
  6. ^ Zill P, Büttner A, Eisenmenger W, Möller HJ, Ackenheil M, Bondy B (2005). "Analysis of tryptophan hydroxylase I and II mRNA expression in the human brain: a post-mortem study". Journal of Psychiatric Research. 41 (1–2): 168–173. doi:10.1016/j.jpsychires.2005.05.004. PMID 16023677.