TPI1

TPI1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IAN, 1WYI, 4POC, 1HTI, 2VOM, 1KLG, 4BR1, 4E41, 4UNK, 2IAM, 1KLU, 2JK2, 4UNL, 4POD, 4ZVJ
Identifiers
Aliases	TPI1, HEL-S-49, TIM, TPI, TPID, triosephosphate isomerase 1
External IDs	OMIM: 190450; MGI: 98797; HomoloGene: 128432; GeneCards: TPI1; OMA:TPI1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.31 Start 6,867,119 bp[1] End 6,870,948 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 F2|6 59.17 cM Start 124,787,549 bp[2] End 124,791,259 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe prefrontal cortex right hemisphere of cerebellum ventricular zone mucosa of transverse colon muscle of thigh Skeletal muscle tissue of rectus abdominis right adrenal gland left adrenal gland right adrenal cortex Top expressed in epithelium of small intestine triceps brachii muscle sternocleidomastoid muscle vastus lateralis muscle temporal muscle intercostal muscle tibialis anterior muscle skeletal muscle tissue gastrocnemius muscle facial motor nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function triose-phosphate isomerase activity protein binding catalytic activity isomerase activity ubiquitin protein ligase binding methylglyoxal synthase activity protein homodimerization activity lyase activity Cellular component cytosol extracellular exosome nucleus extracellular space cytoplasm Biological process canonical glycolysis multicellular organism development gluconeogenesis pentose-phosphate shunt metabolism glyceraldehyde-3-phosphate metabolic process glycolytic process glycerol catabolic process glyceraldehyde-3-phosphate biosynthetic process glucose metabolic process methylglyoxal biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7167 21991 Ensembl ENSG00000111669 ENSMUSG00000023456 UniProt P60174 P17751 RefSeq (mRNA) NM_001258026 NM_000365 NM_001159287 NM_009415 RefSeq (protein) NP_000356 NP_001152759 NP_001244955 NP_033441 Location (UCSC) Chr 12: 6.87 – 6.87 Mb Chr 6: 124.79 – 124.79 Mb PubMed search [3] [4]
Wikidata
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Triosephosphate isomerase is an enzyme that in humans is encoded by the TPI1 gene.

This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehyde 3-phosphate (G3P) and dihydroxyacetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants.^[5]