TRPC4

TRPC4
Identifiers
Aliases	TRPC4, HTRP-4, HTRP4, TRP4, transient receptor potential cation channel subfamily C member 4
External IDs	OMIM: 603651; MGI: 109525; HomoloGene: 22955; GeneCards: TRPC4; OMA:TRPC4 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	37,869,802 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	54,225,892 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; decidua; ; smooth muscle tissue; ; testicle; ; body of uterus; ; right coronary artery; ; myometrium; ; left coronary artery; ; prostate; ; gallbladder;
	Top expressed in
	lateral septal nucleus; ; subiculum; ; Region I of hippocampus proper; ; CA3 field; ; dentate gyrus; ; anterior amygdaloid area; ; hippocampus proper; ; dentate gyrus of hippocampal formation granule cell; ; barrel cortex; ; secondary oocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	beta-catenin binding; store-operated calcium channel activity; cadherin binding; inositol 1,4,5 trisphosphate binding; ion channel activity; protein binding; calcium channel activity;
Cellular component	integral component of membrane; calcium channel complex; membrane; cell-cell junction; cortical cytoskeleton; plasma membrane; cell surface; basolateral plasma membrane; caveola; membrane raft; integral component of plasma membrane; protein-containing complex; cation channel complex;
Biological process	regulation of cytosolic calcium ion concentration; calcium ion import; oligodendrocyte differentiation; ion transport; calcium ion transmembrane transport; manganese ion transport; gamma-aminobutyric acid secretion; calcium ion transport; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	7223
	22066
	ENSG00000133107
	ENSMUSG00000027748
	Q9UBN4
	Q9QUQ5
NM_001135955; NM_001135956; NM_001135957; NM_001135958; NM_003306;
	NM_016179; NM_001354799; NM_001354806; NM_001372055
	NM_001253682; NM_001253683; NM_016984
NP_001129427; NP_001129428; NP_001129429; NP_001129430; NP_003297;
	NP_057263; NP_001341728; NP_001341735; NP_001358984
	NP_001240611; NP_001240612; NP_058680
	Wikidata
View/Edit Human	View/Edit Mouse

The short transient receptor potential channel 4 (TrpC4), also known as Trp-related protein 4, is a protein that in humans is encoded by the TRPC4 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000133107 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027748 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhu X, Jiang M, Peyton M, Boulay G, Hurst R, Stefani E, Birnbaumer L (May 1996). "trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry". Cell. 85 (5): 661–71. doi:10.1016/S0092-8674(00)81233-7. PMID 8646775.
^ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000133107 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027748 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8646775-5] Zhu X, Jiang M, Peyton M, Boulay G, Hurst R, Stefani E, Birnbaumer L (May 1996). "trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry". Cell. 85 (5): 661–71. doi:10.1016/S0092-8674(00)81233-7. PMID 8646775.

[pmid16382100-6] Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.

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