TRPC5

TRPC5
Identifiers
Aliases	TRPC5, PPP1R159, TRP5, transient receptor potential cation channel subfamily C member 5
External IDs	OMIM: 300334; MGI: 109524; HomoloGene: 74915; GeneCards: TRPC5; OMA:TRPC5 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	112,082,776 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	143,471,176 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; prefrontal cortex; ; gastric mucosa; ; ganglionic eminence; ; liver; ; Brodmann area 9; ; primary visual cortex; ; hypothalamus; ; right lobe of liver;
	Top expressed in
	supraoptic nucleus; ; lumbar subsegment of spinal cord; ; dentate gyrus of hippocampal formation granule cell; ; zygote; ; lateral hypothalamus; ; primary visual cortex; ; ventromedial nucleus; ; superior frontal gyrus; ; secondary oocyte; ; dorsomedial hypothalamic nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	inositol 1,4,5 trisphosphate binding; ion channel activity; store-operated calcium channel activity; protein binding; calcium channel activity; clathrin binding; actin binding; actinin binding; ATPase binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; calcium channel complex; membrane; cytoplasm; growth cone; soma; dendrite; membrane raft; cation channel complex;
Biological process	manganese ion transport; ion transport; regulation of cytosolic calcium ion concentration; calcium ion transmembrane transport; calcium ion transport; nervous system development; regulation of membrane hyperpolarization; positive regulation of peptidyl-threonine phosphorylation; positive regulation of axon extension; positive regulation of cell population proliferation; positive regulation of cytosolic calcium ion concentration; neuron differentiation; positive regulation of neuron differentiation; negative regulation of dendrite morphogenesis; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	7224
	22067
	ENSG00000072315
	ENSMUSG00000041710
	Q9UL62
	Q9QX29
	NM_012471
	NM_009428
	NP_036603
	NP_033454
	Wikidata
View/Edit Human	View/Edit Mouse

Short transient receptor potential channel 5 (TrpC5) also known as transient receptor protein 5 (TRP-5) is a protein that in humans is encoded by the TRPC5 gene.^[5]^[6]^[7] TrpC5 is subtype of the TRPC family of mammalian transient receptor potential ion channels.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000072315 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041710 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).
^ Sossey-Alaoui K, Lyon JA, Jones L, Abidi FE, Hartung AJ, Hane B, et al. (September 1999). "Molecular cloning and characterization of TRPC5 (HTRP5), the human homologue of a mouse brain receptor-activated capacitative Ca2+ entry channel". Genomics. 60 (3): 330–340. doi:10.1006/geno.1999.5924. PMID 10493832.
^ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacological Reviews. 57 (4): 427–450. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000072315 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041710 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] Cite error: The named reference entrez was invoked but never defined (see the help page).

[pmid10493832-6] Sossey-Alaoui K, Lyon JA, Jones L, Abidi FE, Hartung AJ, Hane B, et al. (September 1999). "Molecular cloning and characterization of TRPC5 (HTRP5), the human homologue of a mouse brain receptor-activated capacitative Ca2+ entry channel". Genomics. 60 (3): 330–340. doi:10.1006/geno.1999.5924. PMID 10493832.

[pmid16382100-7] Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacological Reviews. 57 (4): 427–450. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.

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