TRPC6

TRPC6
Identifiers
Aliases	TRPC6, FSGS2, TRP6, transient receptor potential cation channel subfamily C member 6
External IDs	OMIM: 603652; MGI: 109523; HomoloGene: 37944; GeneCards: TRPC6; OMA:TRPC6 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	101,872,562 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	8,680,742 bp
RNA expression pattern
	Top expressed in
	right lung; ; upper lobe of left lung; ; right uterine tube; ; testicle; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; Achilles tendon; ; stromal cell of endometrium; ; visceral pleura; ; subcutaneous adipose tissue;
	Top expressed in
	lumbar spinal ganglion; ; right lobe of liver; ; dentate gyrus of hippocampal formation granule cell; ; lens; ; cumulus cell; ; substantia nigra; ; embryo; ; hippocampus proper; ; left lung lobe; ; body of femur;
	More reference expression data
	n/a
Gene ontology
Molecular function	actinin binding; store-operated calcium channel activity; clathrin binding; inositol 1,4,5 trisphosphate binding; ion channel activity; protein binding; actin binding; calcium channel activity; cation channel activity; protein homodimerization activity; ATPase binding;
Cellular component	cytoplasm; integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; slit diaphragm; cation channel complex;
Biological process	regulation of cytosolic calcium ion concentration; positive regulation of cytosolic calcium ion concentration; human ageing; cation transport; ion transport; single fertilization; platelet activation; positive regulation of ion transmembrane transporter activity; negative regulation of dendrite morphogenesis; positive regulation of peptidyl-threonine phosphorylation; calcium ion transmembrane transport; positive regulation of neuron differentiation; neuron differentiation; manganese ion transport; cellular response to hypoxia; calcium ion transport; cellular response to hydrogen peroxide; positive regulation of calcium ion transport; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	7225
	22068
	ENSG00000137672
	ENSMUSG00000031997
	Q9Y210
	Q61143
	NM_004621
	NM_001282086; NM_001282087; NM_013838
	NP_004612
	NP_001269015; NP_001269016; NP_038866
	Wikidata
View/Edit Human	View/Edit Mouse

Transient receptor potential cation channel, subfamily C, member 6 or Transient receptor potential canonical 6, also known as TRPC6, is a protein encoded in the human by the TRPC6 gene. TRPC6 is a transient receptor potential channel of the classical TRPC subfamily.^[5]

TRPC6 channels are nonselective cation channels that respond directly to diacylglycerol (DAG), a product of phospholipase C activity. This activation leads to cellular depolarization and calcium influx.^[5]^[6]

Unlike the closely related TRPC3 channels, TRPC6 channels possess the distinctive ability to transport heavy metal ions. TRPC6 channels facilitate the transport of zinc ions, promoting their accumulation inside cells.^[6]^[7] In addition, despite their non-selectiveness, TRPC6 exhibits a strong preference for calcium ions, with a permeability ratio of calcium to sodium (P_Ca/P_Na) of roughly six. This selectivity is significantly higher compared to TRPC3, which displays a weaker preference for calcium with a (P_Ca/P_Na) ratio of only 1.1.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137672 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031997 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Tang Q, Guo W, Zheng L, Wu JX, Liu M, Zhou X, et al. (July 2018). "Structure of the receptor-activated human TRPC6 and TRPC3 ion channels". Cell Research. 28 (7): 746–755. doi:10.1038/s41422-018-0038-2. PMC 6028632. PMID 29700422.
^ ^a ^b ^c Dietrich A, Gudermann T (2014). "TRPC6: Physiological Function and Pathophysiological Relevance". Mammalian Transient Receptor Potential (TRP) Cation Channels. Handbook of Experimental Pharmacology. Vol. 222. pp. 157–88. doi:10.1007/978-3-642-54215-2_7. ISBN 978-3-642-54214-5. PMID 24756706.
^ Oda S, Nishiyama K, Furumoto Y, Yamaguchi Y, Nishimura A, Tang X, et al. (October 2022). "Myocardial TRPC6-mediated Zn²⁺ influx induces beneficial positive inotropy through β-adrenoceptors". Nature Communications. 13 (1): 6374. Bibcode:2022NatCo..13.6374O. doi:10.1038/s41467-022-34194-9. PMC 9606288. PMID 36289215.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137672 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031997 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Structure-5] Tang Q, Guo W, Zheng L, Wu JX, Liu M, Zhou X, et al. (July 2018). "Structure of the receptor-activated human TRPC6 and TRPC3 ion channels". Cell Research. 28 (7): 746–755. doi:10.1038/s41422-018-0038-2. PMC 6028632. PMID 29700422.

[Springer-6] Dietrich A, Gudermann T (2014). "TRPC6: Physiological Function and Pathophysiological Relevance". Mammalian Transient Receptor Potential (TRP) Cation Channels. Handbook of Experimental Pharmacology. Vol. 222. pp. 157–88. doi:10.1007/978-3-642-54215-2_7. ISBN 978-3-642-54214-5. PMID 24756706.

[7] Oda S, Nishiyama K, Furumoto Y, Yamaguchi Y, Nishimura A, Tang X, et al. (October 2022). "Myocardial TRPC6-mediated Zn²⁺ influx induces beneficial positive inotropy through β-adrenoceptors". Nature Communications. 13 (1): 6374. Bibcode:2022NatCo..13.6374O. doi:10.1038/s41467-022-34194-9. PMC 9606288. PMID 36289215.

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