TRPM2

TRPM2
Identifiers
Aliases	TRPM2, Trpm2, 9830168K16Rik, C79133, LTRPC2, TRPC7, Trp7, Trrp7, EREG1, KNP3, NUDT9H, NUDT9L1, LTrpC-2, transient receptor potential cation channel subfamily M member 2
External IDs	OMIM: 603749; MGI: 1351901; HomoloGene: 20709; GeneCards: TRPM2; OMA:TRPM2 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	44,443,081 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	77,970,563 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; caudate nucleus; ; nucleus accumbens; ; monocyte; ; putamen; ; cingulate gyrus; ; Brodmann area 9; ; anterior cingulate cortex; ; granulocyte; ; right hemisphere of cerebellum;
	Top expressed in
	granulocyte; ; lumbar subsegment of spinal cord; ; mesenteric lymph nodes; ; spleen; ; primary visual cortex; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; blood; ; bone marrow;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium channel activity; sodium channel activity; ion channel activity; cation channel activity; calcium ion binding; calcium-release channel activity; hydrolase activity; ligand-gated calcium channel activity; metal ion binding; ADP-ribose diphosphatase activity; mono-ADP-D-ribose binding;
Cellular component	integral component of membrane; membrane; plasma membrane; lysosome; lysosomal membrane; integral component of plasma membrane; cytoplasmic vesicle membrane; cytoplasmic vesicle; specific granule membrane; cell projection; perikaryon; tertiary granule membrane; ficolin-1-rich granule membrane;
Biological process	sodium ion transmembrane transport; sodium ion transport; cation transport; ion transport; response to oxidative stress; calcium ion transmembrane transport; calcium ion transport; ion transmembrane transport; transmembrane transport; temperature homeostasis; dendritic cell chemotaxis; response to purine-containing compound; calcium-mediated signaling using intracellular calcium source; neutrophil degranulation; release of sequestered calcium ion into cytosol; regulation of filopodium assembly; cellular response to hydrogen peroxide; cellular response to calcium ion; cellular response to purine-containing compound; cellular response to temperature stimulus; zinc ion transmembrane transport; dendritic cell differentiation; calcium ion transmembrane import into cytosol; regulation of actin cytoskeleton reorganization; calcium ion import across plasma membrane; protein homotetramerization;
	Sources:Amigo / QuickGO
Orthologs
	7226
	28240
	ENSG00000142185
	ENSMUSG00000009292
	O94759
	Q91YD4
	NM_001001188; NM_003307; NM_001320350; NM_001320351; NM_001320352
	NM_138301
	NP_001307279; NP_001307280; NP_001307281; NP_003298
	NP_612174
	Wikidata
View/Edit Human	View/Edit Mouse

Transient receptor potential cation channel, subfamily M, member 2, also known as TRPM2, is a protein that in humans is encoded by the TRPM2 gene.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000142185 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000009292 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000142185 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000009292 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

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